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Association of cord blood chemokines and other biomarkers with neonatal complications following intrauterine inflammation

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タイトル: Association of cord blood chemokines and other biomarkers with neonatal complications following intrauterine inflammation
著者: Otsubo, Yoshikazu / Hashimoto, Kunio / Kanbe, Taro / Sumi, Muneichiro / Moriuchi, Hiroyuki
発行日: 2017年 5月22日
出版者: Public Library of Science
引用: PLOS ONE, 12(5), e0175082; 2017
抄録: Background Intrauterine inflammation has been associated with preterm birth and neonatal complications. Few reports have comprehensively investigated multiple cytokine profiles in cord blood and precisely identified surrogate markers for intrauterine inflammation. Aim To identify the cytokines and surrogate markers associated with intrauterine inflammation and subsequent neonatal complications. Patients and methods We analyzed cord blood samples from 135 patients admitted to the neonatal intensive care unit at Sasebo City General Hospital. We retrospectively determined the associations between the presence of neonatal complications and cord blood cytokines, prenatal factors, and laboratory data at birth. A total of 27 cytokines in the cord blood were measured using a bead-based array sandwich immunoassay. Results Both Th1 and Th2 cytokine levels were low, whereas the levels of growth factors and chemokines were high. In particular, chemokines IL-8, MCP-1, and MIP-1α were significantly higher in very premature neonates when compared with more mature neonates. In addition, some have been shown to be associated with multiple neonatal complications, including patent ductus arteriosus (PDA), respiratory distress syndrome (RDS), and chronic lung disease (CLD). Similarly, the levels of N-Terminal pro-brain natriuretic peptide, nucleated RBC, and urinary β2-microglobulin were associated with these complications and chemokine levels. Conclusions Our results suggest the association of inflammatory chemokines IL-8, MCP-1, and MIP-1α with intrauterine inflammation, premature birth, and neonatal complications in these perinatal subjects. Furthermore, the association of the aforementioned biomarkers with PDA, RDS, and CLD may help establish early diagnostic measures to predict such neonatal complications following intrauterine inflammation.
URI: http://hdl.handle.net/10069/37591
DOI: 10.1371/journal.pone.0175082
権利: © 2017 Otsubo et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
資料タイプ: Journal Article
原稿種類: publisher
出現コレクション:130 学術雑誌論文

引用URI : http://hdl.handle.net/10069/37591



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