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Effect of self-reported walking difficulty on bone mass and bone resorption marker in Japanese people aged 40 years and over


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Title: Effect of self-reported walking difficulty on bone mass and bone resorption marker in Japanese people aged 40 years and over
Authors: Abe, Yasuyo / Nishimura, Takayuki / Arima, Kazuhiko / Kanagae, Mitsuo / Mizukami, Satoshi / Tomita, Yoshihito / Okabe, Takuhiro / Goto, Hisashi / Horiguchi, Itsuko / Aoyagi, Kiyoshi
Issue Date: 11-Oct-2016
Publisher: 日本生理人類学会 / Japan Society of Physiological Anthropology
Citation: Journal of Physiological Anthropology, 35(1), 25; 2016
Abstract: Background: This study aimed to examine the association of walking difficulty with bone mass or bone turnover among community-dwelling Japanese people aged 40 years and older. Methods: We studied 1097 community-dwelling Japanese people aged 40 years and older (379 men and 718 women) who were invited to participate in periodic health examinations in 2006–2009. Walking difficulty was defined as having difficulty walking 100 m on a level surface (self-administered questionnaire). Calcaneal stiffness index (bone mass) was measured by quantitative ultrasound. Spot urine samples were collected, and urinary N-terminal cross-linking telopeptide of type I collagen (NTx) was measured. Values were corrected for creatinine (Cre) concentration. Results: The prevalence of walking difficulty was significantly higher in women than in men (7.4 vs. 3.4 %, p = 0.011) and significantly increased with age in men (p for trend = 0.02) and women (p for trend <0.001). In univariate analysis, men and women with walking difficulty were older (p < 0.001) and had a lower stiffness index (p < 0.001), compared with those without walking difficulty. Among women, individuals with walking difficulty had significantly higher urinary NTx/Cre than those without walking difficulty (p < 0.001); however, this was not so among men (p = 0.39). Multiple regression analysis adjusted for age, weight, and menopausal status showed a significant association between walking difficulty and lower stiffness index in men (p = 0.004) and women (p = 0.005). In women, walking difficulty was significantly associated with higher NTx/Cre (p = 0.001), but not in men (p = 0.35). Conclusions: Walking difficulty may contribute to low bone mass in both sexes but might cause high bone turnover in women only.
Keywords: Walking difficulty / Bone mass / Calcaneal stiffness index / Bone turnover
URI: http://hdl.handle.net/10069/37687
DOI: 10.1186/s40101-016-0114-6
Rights: © 2016 The Author(s). Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
Type: Journal Article
Text Version: publisher
Appears in Collections:Articles in academic journal

Citable URI : http://hdl.handle.net/10069/37687

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