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Dengue Associated Acute Encephalitis Syndrome Cases in Son La Province, Vietnam in 2014


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タイトル: Dengue Associated Acute Encephalitis Syndrome Cases in Son La Province, Vietnam in 2014
著者: Ngwe Tun, Mya Myat / Muthugala, Rohitha V. / Thi Thu Thuy, Nguyen / Hoai Linh Ly, Pham / Thi Hien Thu, Le / Thi Dinh, Dang / Viet Hoang, Nguyen / Thi Quynh Mai, Le / Moi, Meng Ling / Buerano, Corazon C. / Morita, Kouichi / Hasebe, Futoshi
発行日: 2017年 7月24日
出版者: 国立感染症研究所 / National Institute of Infectious Diseases
引用: Japanese Journal of Infectious Diseases, 70(4), pp.357-361; 2017
抄録: Acute encephalitis syndrome (AES) is associated with high morbidity and mortality, and affects both children and adults. The main etiologic agent is Japanese encephalitis virus (JEV); however, there are also reports of Dengue virus (DENV) encephalitis. The objectives of this study were to determine the proportion of patients with encephalitis due to JEV during the 2014 outbreak in Son La Province in Vietnam and to explore the association of DENV in non-JEV viral encephalitis cases. Of 90 patients, 6 (6.7%) were positive for anti-JEV immunoglobulin M (IgM), 5 (5.6%) were positive for anti-DENV IgM, 30 (33.3%) were positive for both anti-JEV and anti-DENV IgM, and 56 (62.2%) were positive for flavivirus immunoglobulin G (IgG). In 5 patients with AES, who had positive anti-DENV IgM results in at least one of the paired serum samples, DENV was confirmed by neutralization testing. The incidence of JEV infection was high. There is still a need to maintain and strengthen the national JEV immunization program. This noticeable occurrence of DENV infection was not reported in Son La Province in 2013–2014. Our data suggested that in addition to JEV, DENV was also a causative agent of AES in 2014 in Son La Province, and this finding also confirmed the local occurrence of DENV infection.
キーワード: Japanese encephalitis / Dengue / Acute encephalitis / ELISA / Neutralization test
URI: http://hdl.handle.net/10069/37728
ISSN: 13446304
DOI: 10.7883/yoken.JJID.2016.246
権利: © 2017 National Institute of Infectious Diseases
資料タイプ: Journal Article
原稿種類: publisher
出現コレクション:120 学術雑誌論文

引用URI : http://hdl.handle.net/10069/37728

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