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Low pH-triggering changes in peptide secondary structures


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Title: Low pH-triggering changes in peptide secondary structures
Authors: Furukawa, Kaori / Oba, Makoto / Toyama, Kotomi / Opiyo, George Ouma / Demizu, Yosuke / Kurihara, Masaaki / Doi, Mitsunobu / Tanaka, Masakazu
Issue Date: 14-Aug-2017
Publisher: Royal Society of Chemistry
Citation: Organic and Biomolecular Chemistry, 15(30), pp.6302-6305; 2017
Abstract: We developed a novel methodology using cyclic α,α-disubstituted α-amino acids (dAAs) with an acetal-side chain to control peptide secondary structures. The introduction of cyclic dAAs into peptides contributed to the stabilization of peptide secondary structures as a helix, while an acidic treatment of peptides resulted in a marked conformational change.
URI: http://hdl.handle.net/10069/37739
ISSN: 14770520
DOI: 10.1039/C7OB01374D
Rights: © 2017 Royal Society of Chemistry
Type: Journal Article
Text Version: author
Appears in Collections:Articles in academic journal

Citable URI : http://hdl.handle.net/10069/37739

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