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Ciliated muconodular papillary tumors of the lung with KRAS/BRAF/AKT1 mutation


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タイトル: Ciliated muconodular papillary tumors of the lung with KRAS/BRAF/AKT1 mutation
著者: Udo, Emiko / Furusato, Bungo / Sakai, Kazuko / Prentice, Leah M / Tanaka, Tomonori / Kitamura, Yuka / Tsuchiya, Tomoshi / Yamasaki, Naoya / Nagayasu, Takeshi / Nishio, Kazuto / Fukuoka, Junya
発行日: 2017年 8月22日
出版者: BioMed Central Ltd.
引用: Diagnostic Pathology, 12, 62; 2017
抄録: Background: Ciliated muconodular papillary tumors (CMPTs) are newly recognized rare peripheral lung nodules that are histologically characterized by ciliated columnar, goblet, and basal cells. Although recent studies have shown that CMPTs constitute a neoplastic disease, the complete histogenesis of CMPTs is not fully understood and molecular data are limited. Methods: We reviewed four cases of CMPT and performed immunohistochemical and genomic analyses to establish CMPT profiles. Results: All cases were positive for hepatocyte nuclear factor-4α and mucin 5B and negative for programmed death ligand 1 expression, as determined by immunohistochemistry. The genetic analysis revealed three pathogenic mutations (BRAF V600E, AKT1 E17K, and KRAS G12D), with the KRAS mutation reported here for the first time. Conclusion: Histological and genetic profiles indicate that CMPTs are likely neoplastic and exhibit features similar to mucinous adenocarcinoma. This suggests that some CMPTs may be a precursor lesion of mucinous adenocarcinoma.
キーワード: Ciliated muconodular papillary tumor / CMPT / Next-generation sequencing / Mutation / BRAF / RAS / AKT1
URI: http://hdl.handle.net/10069/37764
DOI: 10.1186/s13000-017-0651-2
権利: © The Author(s). 2017 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
資料タイプ: Journal Article
原稿種類: publisher
出現コレクション:030 学術雑誌論文

引用URI : http://hdl.handle.net/10069/37764

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