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Handgrip strength and subclinical carotid atherosclerosis in relation to platelet levels among hypertensive elderly Japanese


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Title: Handgrip strength and subclinical carotid atherosclerosis in relation to platelet levels among hypertensive elderly Japanese
Authors: Shimizu, Yuji / Sato, Shimpei / Koyamatsu, Jun / Yamanashi, Hirotomo / Nagayoshi, Mako / Kadota, Koichiro / Kawashiri, Shin-Ya / Inoue, Keita / Nagata, Yasuhiro / Maeda, Takahiro
Issue Date: 1-Sep-2017
Publisher: Impact Journals LLC
Citation: Oncotarget, 8(41), pp.69362-69369; 2017
Abstract: Age-related disruption of microvascular endothelium exacerbates hypertension and sarcopenia; and atherosclerosis is a well-known biological response to vascular endothelial injury. Therefore, prevalence of atherosclerosis among hypertensive elderly subjects may partly indicate the presence of an appropriate response to endothelial injury. We conducted a cross-sectional study of 795 elderly hypertensive Japanese subjects aged 60-89 years. Since platelet level is an indicator of vascular repair activity, subjects were stratified by platelet counts. No significant association between handgrip strength and subclinical carotid atherosclerosis (carotid intima-media thickness (CIMT) ≥1.1mm) was observed for subjects with lower platelet counts, while a significant positive association was observed for subjects with higher platelets. Adjusted odds and 95% confidence intervals of subclinical carotid atherosclerosis for 1 standard deviation increments in handgrip strength were 0.86 (0.61, 1.22) for subjects with lower platelets and 1.82 (1.26, 2.64) for subjects with higher platelets. A positive association between handgrip strength and subclinical carotid atherosclerosis exists in hypertensive elderly subjects with higher, but not lower, platelet counts. These results lead us to speculate that subjects with a beneficial influence on prevention of sarcopenia (maintenance of handgrip strength) may possess the capacity of active endothelial repair that causes atherosclerosis.
Keywords: atherosclerosis / handgrip / hypertension / platelet / sarcopenia / Gerotarget
URI: http://hdl.handle.net/10069/37863
DOI: 10.18632/oncotarget.20618
Rights: © 2017 Impact Journals, LLC / This article is licensed under a Creative Commons Attribution 3.0 License.
Type: Journal Article
Text Version: publisher
Appears in Collections:Articles in academic journal

Citable URI : http://hdl.handle.net/10069/37863

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