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Clinical, virological and epidemiological characterization of dengue outbreak in Myanmar, 2015

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タイトル: Clinical, virological and epidemiological characterization of dengue outbreak in Myanmar, 2015
その他のタイトル: 2015年にミャンマー国で発生したデング熱流行の臨床、ウイルス学、疫学解析
著者: Kyaw, Aung Kyaw
著者(別表記) : キョウ, アウン キョウ
発行日: 2017年 9月20日
出版者: Cambridge University Press
引用: Nagasaki University (長崎大学), 博士(医学) (2017-09-20)
抄録: Hospital-based surveillance was conducted at two widely separated regions in Myanmar during the 2015 dengue epidemic. Acute phase serum samples were collected from 332 clinically diagnosed dengue patients during the peak season of dengue cases. Viremia levels were measured by quantitative real-time PCR and plaque assays using FcγRIIA-expressing and non-FcγRIIA-expressing BHK cells to specifically determine the infectious virus particles. By serology and molecular techniques, 280/332 (84·3%) were confirmed as dengue patients. All four serotypes of dengue virus (DENV) were isolated from among 104 laboratory-confirmed patients including two cases infected with two DENV serotypes. High percentage of primary infection was noted among the severe dengue patients. Patients with primary infection or DENV IgM negative demonstrated significantly higher viral loads but there was no significant difference among the severity groups. Viremia levels among dengue patients were notably high for a long period which was assumed to support the spread of the virus by the mosquito vector during epidemic. Phylogenetic analyses of the envelope gene of the epidemic strains revealed close similarity with the strains previously isolated in Myanmar and neighboring countries. DENV-1 dominated the epidemic in 2015 and the serotype (except DENV-3) and genotype distributions were similar in both study sites.
記述: 長崎大学学位論文 学位記番号:博(医歯薬)甲第984号 学位授与年月日:平成29年9月20日 / Author: A. K. KYAW, M. M. NGWE TUN, M. L. MOI, T. NABESHIMA, K. T. SOE, S. M. THWE, A. A. MYINT, K. T. T. MAUNG, W. AUNG, D. HAYASAKA, C. C. BUERANO, K. Z. THANT and K. MORITA / Citation: Epidemiology & Infection, 145(9), pp.1886-1897; 2017
キーワード: Clinical / molecular epidemiology / Myanmar / viremia / 2015 dengue outbreak
URI: http://hdl.handle.net/10069/37888
ISSN: 09502688
DOI: 10.1017/S0950268817000735
関連リンク : http://hdl.handle.net/10069/37795
権利: © Cambridge University Press 2017 / This article has been published in a revised form in Epidemiology & Infection, http://doi.org/10.1017/S0950268817000735. This version is free to view and download for private research and study only. Not for re-distribution, re-sale or use in derivative works.
資料タイプ: Thesis or Dissertation
原稿種類: ETD
出現コレクション:110 学位論文

引用URI : http://hdl.handle.net/10069/37888



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