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Association of RSV-A ON1 genotype with Increased Pediatric Acute Lower Respiratory Tract Infection in Vietnam


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タイトル: Association of RSV-A ON1 genotype with Increased Pediatric Acute Lower Respiratory Tract Infection in Vietnam
その他のタイトル: ベトナムにおけるRSウイルスサブグループA遺伝子型ON1と小児下気道感染症増加との関連
著者: 吉原, 圭亮
著者(別表記) : Yoshihara, Keisuke
発行日: 2017年 9月20日
出版者: Macmillan Publishers Limited
引用: Nagasaki University (長崎大学), 博士(医学) (2017-09-20)
抄録: Since the initial discovery of RSV-A ON1 in Canada in 2010, ON1 has been reported worldwide, yet information regarding its clinical impact and severity has been controversial. To investigate the clinical relevance of RSV-A ON1,acute respiratory infection (ARI) cases enrolled to our population-based prospective pediatric ARI surveillance at Khanh Hoa General Hospital, Central Vietnam from January 2010 through December 2012 were studied. Clinical-epidemiological information and nasopharyngeal samples were collected. Multiplex PCR assays were performed for screening 13 respiratory viruses. RSV-positive samples were further tested for subgroups (A/B) and genotypes information by sequencing the G-glycoprotein 2nd hypervariable region. Statistical analysis was performed to evaluate the clinical-epidemiological characteristics of RSV-A ON1. A total of 1854 ARI cases were enrolled and 426 (23.0%) of them were RSV-positive. During the study period, RSV-A and B had been co-circulating. NA1 was the predominant RSV-A genotype until the appearance of ON1 in 2012. RSV-related ARI hospitalization incidence significantly increased after the emergence of ON1. Moreover, multivariate analysis revealed that risk of lower respiratory tract infection was 2.26 (95% CI: 1.37–3.72) times, and radiologically-confirmed pneumonia was 1.98 (95% CI: 1.01–3.87) times greater in ON1 compared to NA1 cases. Our result suggested that ON1 ARI cases were clinically more severe than NA1.
記述: 長崎大学学位論文 学位記番号:博(医歯薬)甲第999号 学位授与年月日:平成29年9月20日 / Author: Keisuke Yoshihara, Minh Nhat Le, Michiko Okamoto, Anita Carolle Akpeedje Wadagni, Hien Anh Nguyen, Michiko Toizumi, Enga Pham, Motoi Suzuki, Ai Thi Thuy Nguyen, Hitoshi Oshitani, Koya Ariyoshi, Hiroyuki Moriuchi, Masahiro Hashizume, Duc Anh Dang & Lay-Myint Yoshida / Citation: Scientific Reports, 6, 27856; 2016 C
URI: http://hdl.handle.net/10069/37901
DOI: 10.1038/srep27856
関連リンク : http://hdl.handle.net/10069/37810
権利: © The Author(s) 2016. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
資料タイプ: Thesis or Dissertation
原稿種類: ETD
出現コレクション:110 学位論文

引用URI : http://hdl.handle.net/10069/37901

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