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Identification of novel antiviral of fungus-derived brefeldin A against dengue viruses


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タイトル: Identification of novel antiviral of fungus-derived brefeldin A against dengue viruses
著者: Raekiansyah, Muhareva / Mori, Mihoko / Nonaka, Kenichi / Agoh, Masanobu / Shiomi, Kazuro / Matsumoto, Atsuko / Morita, Kouichi
発行日: 2017年10月26日
出版者: BioMed Central Ltd.
引用: Tropical Medicine and Health, 45, 32; 2017
抄録: Microbial natural products possess a wide range of biological and biochemical potential. Among them, fungal secondary metabolites are one of the most important sources for discovering new drugs or lead compounds. In the present study, we explored substances produced by the strain Penicillium sp. FKI-7127 for its antiviral activity. We identified brefeldin A as a novel antiviral agent against dengue viruses. The inhibitory effect of brefeldin A was confirmed by virus titer and immunofluorescence assay. Brefeldin A inhibited dengue viruses regardless of serotypes and other related viruses including Zika virus and Japanese encephalitis virus. Time-of-addition study showed that brefeldin A exerts its antiviral effect at an early stage of the dengue virus (DENV) life cycle. These studies demonstrate that (i) brefeldin A could be used as a lead compound for drug development of anti-DENV and other related viruses and (ii) fungal metabolites are a potential and valuable source for dengue virus drug discovery.
キーワード: Dengue virus / Antiviral / Brefeldin A / Secondary metabolite / Fungus
URI: http://hdl.handle.net/10069/37906
DOI: 10.1186/s41182-017-0072-7
権利: © The Author(s). 2017 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
資料タイプ: Journal Article
原稿種類: publisher
出現コレクション:120 学術雑誌論文

引用URI : http://hdl.handle.net/10069/37906

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