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Glucose fluctuations reduce quality of sleep and of life in patients with liver cirrhosis


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タイトル: Glucose fluctuations reduce quality of sleep and of life in patients with liver cirrhosis
その他のタイトル: 肝硬変患者における血糖変動と睡眠障害およびQOLとの関連についての検討
著者: 原口, 雅史
著者(別表記) : Haraguchi, Masafumi
発行日: 2017年 3月21日
出版者: Springer
引用: Nagasaki University (長崎大学), 博士(医学) (2017-03-21)
抄録: Background: Sleep disturbance and decreased health-related quality of life (HRQOL) are significant complaints in patients with liver cirrhosis. Although the etiology of these complications is unclear, we propose that glucose intolerance may be a predisposing factor. Therefore, our aim was to investigate the relationship between glucose intolerance and these complications. Methods: We assessed continuous glucose monitoring in 43 patients with chronic liver disease. Among these patients, 36 completed the Pittsburgh Sleep Quality Index (PSQI), the 36-Item Short-form Health Survey (SF-36), and the Neuropsychological Test (NPT). We also assessed the change in glucose fluctuations between preoperative periods and 1 year after liver transplantation in 13 patients. Results: Standard deviation (SD) of blood glucose was 24.15 ± 13.52. SD values correlated to glucose metabolism measures, including HbA1c and glycoalbumin. SD values also correlated to markers of liver fibrosis, including type IV collagen. Twenty-one patients (58.3 %) were classified as “poor” sleepers, with a global PSQI score ≥6. Glucose fluctuations correlated with the global PSQI score (r = 0.456, p = 0.008) and the SF-36 score (r = 0.434, p = 0.013). Multivariate regression analysis identified SD values as an independent risk factor for sleep disturbance (r = 0.12, p = 0.039) and decreased HRQOL (r = −0.32, p = 0.024). SD values did not correlate with the NPT. SD values were also improved in 11 (84.6 %) patients 1 year after liver transplantation. Conclusion: Abnormal glucose fluctuations are a risk factor for sleep disturbance and decrease of HRQOL in patients with cirrhosis.
記述: 長崎大学学位論文 学位記番号:博(医歯薬)甲第930号 学位授与年月日:平成29年3月21日
キーワード: Cirrhosis / Glucose fluctuations / Sleep disturbance / Health-related quality of life
URI: http://hdl.handle.net/10069/37946
ISSN: 19360533
DOI: 10.1007/s12072-016-9762-1
関連リンク : http://hdl.handle.net/10069/37207
権利: © Asian Pacific Association for the Study of the Liver 2016 / The final publication is available at www.springerlink.com
資料タイプ: Thesis or Dissertation
原稿種類: ETD
出現コレクション:110 学位論文

引用URI : http://hdl.handle.net/10069/37946

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