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Early effects of parathyroid hormone on bisphosphonate/steroid-associated compromised osseous wound healing


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タイトル: Early effects of parathyroid hormone on bisphosphonate/steroid-associated compromised osseous wound healing
著者: Kuroshima, Shinichiro / Entezami, P. / McCauley, L. K. / Yamashita, J.
発行日: 2014年 3月
出版者: Springer London
引用: Osteoporosis International, 25(3), pp.1141-1150; 2014
抄録: Summary: Administration of intermittent parathyroid hormone (PTH) promoted healing of tibial osseous defects and tooth extraction wounds and prevented the development of necrotic lesions in rats on a combined bisphosphonate and steroid regimen. Introduction: Osteonecrosis of the jaw (ONJ) has emerged in association with antiresorptive therapies. The pathophysiology of ONJ is unknown and no established cure currently exists. Our objective was to determine the effect of intermittent PTH administration on early osseous healing in the jaw and long bones of rats receiving bisphosphonate and steroid treatment. Methods: Ovariectomized rats received the combination therapy of alendronate and dexamethasone (ALN/DEX) for 12 weeks. Osseous wounds were created in the jaw and tibia. PTH was administered intermittently and healing at 2 weeks post-op was compared between the jaw and tibia by microcomputed tomography and histomorphometric analyses. Results: ALN/DEX treatment was associated with necrotic open wounds in the jaw but had no negative effects on healing and promoted bone fill in tibial defects. PTH therapy prevented the development of necrotic lesions in the jaw and promoted healing of the tibial defects. PTH therapy was associated with the promotion of osteocyte survival in osseous wounds both in the jaw and tibia. Conclusions: Wound healing was impaired in the jaw in rats on a combined bisphosphonate and steroid regimen, and PTH therapy rescued necrotic lesions. These findings suggest that PTH therapy could be utilized to prevent ONJ from occurring in patients on combination antiresorptive and steroid therapy.
キーワード: Alendronate / Bisphosphonate-associated osteonecrosis of the Jaw / Parathyroid hormone / Wound healing
URI: http://hdl.handle.net/10069/37947
ISSN: 0937941X
DOI: 10.1007/s00198-013-2570-8
権利: © The Author(s) 2013. This article is published with open access at Springerlink.com
資料タイプ: Journal Article
原稿種類: publisher
出現コレクション:130 学術雑誌論文

引用URI : http://hdl.handle.net/10069/37947

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