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Association of cord blood chemokines and other biomarkers with neonatal complications following intrauterine inflammation

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タイトル: Association of cord blood chemokines and other biomarkers with neonatal complications following intrauterine inflammation
その他のタイトル: 子宮内炎症に伴う新生児合併症と臍帯血ケモカイン、バイオマーカーとの関連
著者: 大坪, 善数
著者(別表記) : Otsubo, Yoshikazu
発行日: 2017年12月31日
出版者: Public Library of Science
引用: Nagasaki University (長崎大学), 博士(医学) (2017-12-31)
抄録: Background: Intrauterine inflammation has been associated with preterm birth and neonatal complications. Few reports have comprehensively investigated multiple cytokine profiles in cord blood and precisely identified surrogate markers for intrauterine inflammation. Aim: To identify the cytokines and surrogate markers associated with intrauterine inflammation and subsequent neonatal complications. Patients and methods: We analyzed cord blood samples from 135 patients admitted to the neonatal intensive care unit at Sasebo City General Hospital. We retrospectively determined the associations between the presence of neonatal complications and cord blood cytokines, prenatal factors, and laboratory data at birth. A total of 27 cytokines in the cord blood were measured using a bead-based array sandwich immunoassay. Results: Both Th1 and Th2 cytokine levels were low, whereas the levels of growth factors and chemokines were high. In particular, chemokines IL-8, MCP-1, and MIP-1α were significantly higher in very premature neonates when compared with more mature neonates. In addition, some have been shown to be associated with multiple neonatal complications, including patent ductus arteriosus (PDA), respiratory distress syndrome (RDS), and chronic lung disease (CLD). Similarly, the levels of N-terminal pro-brain natriuretic peptide, nucleated RBC, and urinary β2-microglobulin were associated with these complications and chemokine levels. Conclusions: Our results suggest the association of inflammatory chemokines IL-8, MCP-1, and MIP-1α with intrauterine inflammation, premature birth, and neonatal complications in these perinatal subjects. Furthermore, the association of the aforementioned biomarkers with PDA, RDS, and CLD may help establish early diagnostic measures to predict such neonatal complications following intrauterine inflammation.
記述: 長崎大学学位論文 学位記番号:博(医歯薬)甲第1002号 学位授与年月日:平成29年12月31日 / Author: Yoshikazu Otsubo, Kunio Hashimoto, Taro Kanbe, Muneichiro Sumi, Hiroyuki Moriuchi / Citation: PLoS ONE, 12(5), e0175082; 2017
URI: http://hdl.handle.net/10069/37982
DOI: 10.1371/journal.pone.0175082
関連リンク : http://hdl.handle.net/10069/37919
権利: © 2017 Otsubo et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
資料タイプ: Thesis or Dissertation
原稿種類: ETD
出現コレクション:110 学位論文

引用URI : http://hdl.handle.net/10069/37982



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