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One-step formation of lipid-polyacrylic acid-calcium carbonate nanoparticles for co-delivery of doxorubicin and curcumin

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Title: One-step formation of lipid-polyacrylic acid-calcium carbonate nanoparticles for co-delivery of doxorubicin and curcumin
Authors: Peng, Jianqing / Fumoto, Shintaro / Miyamoto, Hirotaka / Chen, Yi / Kuroda, Naotaka / Nishida, Koyo
Issue Date: 2-May-2017
Publisher: Informa UK Limited
Citation: Journal of Drug Targeting, 25(8), pp.704-714; 2017
Abstract: A doxorubicin (Dox) and curcumin (Cur) combination treatment regimen has been widely studied in pre-clinical research. However, the nanoparticles developed for this combination therapy require a consecutive drug loading process because of the different water-solubility of these drugs. This study provides a strategy for the “one-step” formation of nanoparticles encapsulating both Dox and Cur. We took advantage of polyacrylic acid (PAA) and calcium carbonate (CaCO3) to realise a high drug entrapment efficiency (EE) and pH-sensitive drug release using a simplified preparation method. Optimisation of lipid ratios and concentrations of CaCO3 was conducted. Under optimal conditions, the mean diameter of PEGylated lipid/PAA/CaCO3 nanoparticles with encapsulated Cur and Dox (LPCCD) was less than 100 nm. An obvious pH-sensitive release of both drugs was observed, with different Dox and Cur release rates. Successful co-delivery of Cur and Dox was achieved via LPCCD on HepG2 cells. LPCCD altered the bio-distribution of Dox and Cur in vivo and decreased Dox-induced cardiotoxicity. The current investigation has developed an efficient ternary system for co-delivery of Dox and Cur to tumours, using a “one-step” formation resulting in nanoparticles possessing remarkable pH-sensitive drug release behaviour, which may be valuable for further clinical studies and eventual clinical application.
Keywords: Doxorubicin / curcumin / polyacrylic acid / calcium carbonate / lipid nanoparticle
URI: http://hdl.handle.net/10069/37987
ISSN: 1061186X
DOI: 10.1080/1061186X.2017.1315687
Rights: © 2017 Informa UK Limited / This is an Accepted Manuscript of an article published by Taylor & Francis Group in Journal of Drug Targeting on 02 May 2017, available online: http://www.tandfonline.com/10.1080/1061186X.2017.1315687
Type: Journal Article
Text Version: author
Appears in Collections:Articles in academic journal

Citable URI : http://hdl.handle.net/10069/37987

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