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Lower gingival squamous cell carcinoma with brain metastasis during long-term cetuximab treatment: A case report


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Title: Lower gingival squamous cell carcinoma with brain metastasis during long-term cetuximab treatment: A case report
Authors: Naruse, Tomofumi / Tokuhisa, Mitsuko / Yanamoto, Souichi / Sakamoto, Yuki / Okuyama, Kohei / Tsuchihashi, Hiroki / Umeda, Masahiro
Issue Date: May-2018
Publisher: Spandidos Publications
Citation: Oncology Letters, 15(5), pp.7158-7162; 2018
Abstract: Long-term cetuximab treatment can lead to acquired resistance, and tumor progression and/or new lesions often occur. The present report describes a case of lower gingival squamous cell carcinoma with brain metastasis during long-term cetuximab treatment in a 60-year-old man, including findings of an immunohistochemical study. The resected primary tumors, biopsy of the lung metastasis before administration of cetuximab, and brain metastasis specimens mediated by cetuximab were immunohistochemically examined. Histologically, the metastatic brain lesion showed hyperkeratinizing tumor cells with deeply stained irregular nuclei with necrotizing tumor cells, and a decrease in cell density was exhibited in part of the tumor nest. Moreover, the brain lesion was less malignant compared with the primary tumor and metastatic lung lesions. Immunohistochemically, the metastatic brain lesions showed low expression of epidermal growth factor receptor (EGFR) and high expression of N-cadherin compared with the primary tumor and metastatic lung lesions. These results suggest that acquired resistance to cetuximab may be associated with low EGFR expression and increased epithelial-to-mesenchymal transition potential.
Keywords: Brain metastasis / Cetuximab resistance / Epidermal growth factor receptor / Epithelial-to-mesenchymal transition / Oral squamous cell carcinoma
URI: http://hdl.handle.net/10069/38240
ISSN: 17921074
DOI: 10.3892/ol.2018.8261
Rights: © Naruse et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
Type: Journal Article
Text Version: publisher
Appears in Collections:Articles in academic journal

Citable URI : http://hdl.handle.net/10069/38240

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