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An unusual presentation of adult T-cell leukemia/lymphoma


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Title: An unusual presentation of adult T-cell leukemia/lymphoma
Authors: Tag-Adeen, Mohammed / Hashiguchi, Keiichi / Akazawa, Yuko / Ohnita, Ken / Yasushi, Sawayama / Daisuke, Niino / Nakao, Kazuhiko
Issue Date: 23-Jan-2018
Publisher: Cancer Intellilgence
Citation: ecancermedicalscience, 12, 801; 2018
Abstract: Adult T-cell Leukemia/Lymphoma (ATL) is a rare disease, related to human T-lymphotropic virus-1 (HTLV-1) and presented mainly in adulthood by generalised lymphadenopathy, hepatosplenomegaly, skin lesions and hypercalcaemia, with rare gastrointestinal and/or oral manifestations. We reported this case to raise awareness and demonstrate the therapeutic challenges of this rare disease. A 49-year-old Japanese female presented with skin papules on both forearms, painful mouth ulcers and multiple neck swellings since early February 2017. Initial clinical examination and laboratory investigations were misleading and her condition was diagnosed as candidiasis. Because of un-improvement of the case, a screening upper endoscopy was requested 2 months later and revealed characteristic oropharyngeal ulcers which were biopsied, and its pathologic examination confirmed smouldering type ATL. This case report should raise awareness of doctors and endoscopists about this disease especially in HTLV-1 endemic areas to avoid late diagnosis and help achieve earlier therapeutic decisions.
Keywords: Adult T-Cell leukaemia/lymphoma / Endoscopic findings / Human T-lymphotropic virus / Oral ulcers / Oropharyngeal ulcers
URI: http://hdl.handle.net/10069/38267
DOI: 10.3332/ecancer.2018.801
Rights: © the authors; licensee ecancermedicalscience. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Type: Journal Article
Text Version: publisher
Appears in Collections:Articles in academic journal

Citable URI : http://hdl.handle.net/10069/38267

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