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院内製剤2.0%ガンシクロビル点眼液の安全性に関する検討


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Title: 院内製剤2.0%ガンシクロビル点眼液の安全性に関する検討
Other Titles: Evaluation of the Safety of 2.0% Ganciclovir Eye Drops for Hospital Preparation
Authors: 中川, 博雄 / 松丸, 由美 / 能勢, 誠一 / 佐々木, 均 / 北原, 隆志
Authors (alternative): Nakagawa, Hiroo / Matsumaru, Yumi / Nose, Seiichi / Sasaki, Hitoshi / Kitahara, Takashi
Issue Date: 1-Jan-2018
Publisher: 日本薬学会 / Pharmaceutical Society of Japan
Citation: Yakugaku Zasshi, 138(1), pp.107-110; 2018
Abstract: The concentration of ganciclovir eye drops for hospital preparation was changed from 0.5% to 2.0% at the Nagasaki University Hospital from March 2015. We investigated the incidence of side effects in 12 patients using 2.0% ganciclovir eye drops and evaluated the cytotoxicity of 2.0% ganciclovir eye drops using cultured rabbit corneal cells in vitro. As a side effect of 2.0% ganciclovir eye drops, three patients exhibited an early feeling of transient stimulation. The 2.0% ganciclovir eye drops did not demonstrate cell cytotoxicity for cultured corneal cells after 5 min, but did after 10 min. These findings suggested that the 2.0% ganciclovir eye drops can be used without corneal epithelium disorder in clinical settings.
Keywords: 2.0% ganciclovir eye drop / Corneal cell / Cytotoxicity / Hospital preparation / Side effect
URI: http://hdl.handle.net/10069/38288
ISSN: 00316903
DOI: 10.1248/yakushi.17-00015
Rights: © 2018 The Pharmaceutical Society of Japan
Type: Journal Article
Text Version: publisher
Appears in Collections:Articles in academic journal

Citable URI : http://hdl.handle.net/10069/38288

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