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Adjunctive corticosteroid therapy for inpatients with Mycoplasma pneumoniae pneumonia

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Title: Adjunctive corticosteroid therapy for inpatients with Mycoplasma pneumoniae pneumonia
Authors: Tashiro, Masato / Fushimi, Kiyohide / Kawano, Kei / Takazono, Takahiro / Saijo, Tomomi / Yamamoto, Kazuko / Kurihara, Shintaro / Imamura, Yoshifumi / Miyazaki, Taiga / Yanagihara, Katsunori / Mukae, Hiroshi / Izumikawa, Koichi
Issue Date: 29-Dec-2017
Publisher: BMC Pulmonary Medicine
Citation: BMC Pulmonary Medicine, 17, 219; 2017
Abstract: Background: There is conflicting evidence regarding the benefit of adjunctive corticosteroid therapy in patients with Mycoplasma pneumoniae pneumonia. We hypothesised that corticosteroid therapy could reduce mortality and length of stay (LOS) in such patients. Methods: Adult patients with M. pneumoniae pneumonia from January 2010 to December 2013 were identified from the Japanese Diagnosis Procedure Combination inpatient database. The effects of low-dose and high-dose corticosteroid therapies on mortality, LOS, drug costs and hyperglycaemia requiring insulin treatment were evaluated using propensity score analyses. Results: Eligible patients (n=2228) from 630 hospitals were divided into no-corticosteroid (n=1829), low-dose corticosteroid (n=267) and high-dose corticosteroid (n=132) groups. The propensity score-matched pairs were generated from no-corticoid and low-dose corticoid groups (251 pairs), or no-corticoid and high-dose corticosteroid groups (120 pairs). Adjunctive corticosteroid therapy did not decrease 30-day mortality. In addition, both low-dose and high-dose corticosteroid therapies were associated with increases in LOS. Furthermore, hyperglycaemia requiring insulin treatment and drug cost increased with corticosteroid use. Conclusions: Adjunctive treatment with low-dose or high-dose corticosteroids may not be beneficial in M. pneumoniae pneumonia.
Keywords: Corticosteroid / Mycoplasma pneumoniae / Pneumonia
URI: http://hdl.handle.net/10069/38294
DOI: 10.1186/s12890-017-0566-4
Rights: © 2018 The Author(s). This article is distributed under the terms of theCreative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
Type: Journal Article
Text Version: publisher
Appears in Collections:Articles in academic journal

Citable URI : http://hdl.handle.net/10069/38294

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