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Current characteristics of hemophilia patients co‑infected with HIV/HCV in Japan


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Title: Current characteristics of hemophilia patients co‑infected with HIV/HCV in Japan
Authors: Miuma, Satoshi / Hidaka, Masaaki / Takatsuki, Mitsuhisa / Natsuda, Koji / Soyama, Akihiko / Miyaaki, Hisamitsu / Kanda, Yasuko / Tamada, Yoko / Shibata, Hidetaka / Ozawa, Eisuke / Taura, Naota / Eguchi, Susumu / Nakao, Kazuhiko
Issue Date: Feb-2018
Publisher: Spandidos Publications
Citation: Experimental and Therapeutic Medicine, 15(2), pp.2148-2155; 2018
Abstract: Over 30 years have passed since co-infection with human immunodeficiency virus (HIV)/hepatitis C virus (HCV) was first documented in hemophilia patients in Japan. In such cases, the leading cause of mortality is reportedly HCV-associated end-stage liver disease. However, the current characteristics of hemophilia patients co-infected with HIV/HCV are unknown. The aim of the present study was to reveal the current characteristics, notably HCV geno-prevalence and liver function, among hemophilia patients co-infected with HIV/HCV in Japan. Current characteristics were evaluated using cross-sectional retrospective data of 44 hemophilia patients positive for anti-HCV and anti-HIV antibodies who underwent screening of liver dysfunction. A total of 56.8% of hemophilia patients co-infected with HIV/HCV were positive for HCV RNA. The most common HCV genotypes were 1a, 1b and 3a. Liver cirrhosis was diagnosed in 26.3% patients negative for HCV RNA and 60.0% patients positive for HCV RNA. Decompensated liver cirrhosis was diagnosed in 33.3% HCV RNA-positive patients and none of the HCV RNA-negative patients. The rate of liver cirrhosis was greater for HCV genotype 3a compared with other genotypes. Overall, the current primary HCV RNA genotypes among hemophilia patients co-infected with HIV/HCV are 1a, 1b and 3a. Over 50% of HIV/HCV co-infected hemophilia patients positive for HCV RNA were diagnosed with liver cirrhosis and some were diagnosed with decompensated liver cirrhosis.
Keywords: Genotype / Hemophilia / Hepatitis C virus / Human immunodeficiency virus / Livercirrhosis
URI: http://hdl.handle.net/10069/38297
ISSN: 17920981
DOI: 10.3892/etm.2017.5603
Rights: © 2018, Spandidos Publications. All rights reserved.
Type: Journal Article
Text Version: publisher
Appears in Collections:Articles in academic journal

Citable URI : http://hdl.handle.net/10069/38297

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