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Hepatocyte growth factor and carotid intima-media thickness in relation to circulating CD34-positive cell levels


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タイトル: Hepatocyte growth factor and carotid intima-media thickness in relation to circulating CD34-positive cell levels
著者: Shimizu, Yuji / Sato, Shimpei / Koyamatsu, Jun / Yamanashi, Hirotomo / Nagayoshi, Mako / Kawashiri, Shin-Ya / Inoue, Keita / Fukui, Shoichi / Kondo, Hideaki / Nakamichi, Seiko / Nagata, Yasuhiro / Maeda, Takahiro
発行日: 2018年 5月 3日
出版者: BioMed Central Ltd
引用: Environmental Health and Preventive Medicine, 23, 16; 2018
抄録: Hepatocyte growth factor (HGF) may act as a possible biochemical index for vascular damage, although evidence for the association between HGF and carotid intima-media thickness (CIMT) is limited. Since both HGF and circulating CD34-positive cells play an important role in endothelial repair, circulating CD34-positive cell levels may influence the association between HGF and CIMT. Methods: We conducted a cross-sectional study of 269 elderly Japanese men aged 60-69 years who had undertaken an annual medical checkup from 2014 to 2015. Results: The median value for circulating CD34-positive cells was 0.93 cells/μL. Among the study population, 135 men showed low circulating CD34-positive cell levels (≤ 0.93 cells/μL). By multivariable linear regression analysis, HGF was found to be significantly positively associated with CIMT only to participants with low circulating CD34-positive cell levels, with a multi-adjusted β of 0.26 (p = 0.005) and 0.002 (0.986) for low and high circulating CD34-positive cell levels, respectively. In addition, a significant interaction was observed between HGF and circulating CD34-positive cell levels (low and high) on CIMT (multivariable p value of 0.049). A positive association exists between HGF and CIMT in elderly Japanese men, limited to participants with low circulating CD34-positive cell levels. Conclusion: A positive association exists between HGF and CIMT in community-dwelling elderly Japanese men, which is limited to participants with low numbers of circulating CD34-positive cells. Our findings indicate that circulating CD34-positive cell levels could determine the influence of HGF on CIMT in elderly Japanese men.
キーワード: CD34-positive cell / CIMT / Elderly men / Endothelial repair / HGF
URI: http://hdl.handle.net/10069/38299
ISSN: 1342078X
DOI: 10.1186/s12199-018-0705-4
権利: © 2018 The Author(s). This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
資料タイプ: Journal Article
原稿種類: publisher
出現コレクション:110 学術雑誌論文

引用URI : http://hdl.handle.net/10069/38299

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