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CD4+ CD52lo T-cell expression contributes to the development of systemic lupus erythematosus


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Title: CD4+ CD52lo T-cell expression contributes to the development of systemic lupus erythematosus
Other Titles: CD4+ CD52lo T細胞発現は全身性エリテマトーデスの病態形成に関与する
Authors: 梅田, 雅孝
Authors (alternative): Umeda, Masataka
Issue Date: 20-Mar-2018
Publisher: Elsevier Inc.
Citation: Nagasaki University (長崎大学), 博士(医学) (2018-03-20)
Abstract: The cell-surface glycoprotein CD52 is widely expressed in lymphocytes. CD4+ CD52hi T cells are functioning suppressor CD4+ T cells. We investigated the role of the immune regulation of CD4+ CD52 T cells in systemic lupus erythematosus (SLE). CD4+ CD52lo T cells were increased in SLE patients, in positive correlation with SLEDAI, anti-ds-DNA antibody, and IgG concentration. Circulating follicular helper-like T cells (Tfh-like cells) were also increased in SLE, in positive correlation with CD4+ CD52lo T cells. Chemokine receptor 8 (CCR8) expression in CD4+ CD52lo T cells was increased. In vitro experiments using CD4 T cells of SLE patients showed that thymus and activation-regulated chemokine (TARC), a ligand of CCR8, contributed to the development of CD4+ CD52hi T cells into CD4+ CD52lo T cells. Our findings suggest that CD4 + CD52lo T-cell upregulation is involved in the production of pathogens by autoantibodies, and TARC may contribute to the development of SLE through an aberrant induction of CD4+ CD52lo T cells.
Description: 長崎大学学位論文 学位記番号:博(医歯薬)甲第1044号 学位授与年月日:平成30年3月20日 / Author: Masataka Umeda, Tomohiro Koga, Kunihiro Ichinose, Takashi Igawa, Tomohito Sato, Ayuko Takatani, Toshimasa Shimizu, Shoichi Fukui, Ayako Nishino, Yoshiro Horai, Yasuko Hirai, Shin-ya Kawashiri, Naoki Iwamoto, Toshiyuki Aramaki, Mami Tamai, Hideki Nakamura, Kazuo Yamamoto, Norio Abiru, Tomoki Origuchi, Yukitaka Ueki, Atsushi Kawakami / Citation: Clinical Immunology, 187, pp.50-57; 2018
Keywords: CD52 / T cells / Systemic lupus erythematosus
URI: http://hdl.handle.net/10069/38323
ISSN: 15216616
DOI: 10.1016/j.clim.2017.10.004
Relational Links: http://hdl.handle.net/10069/38086
Rights: © 2017 Elsevier Inc. All rights reserved.
Type: Thesis or Dissertation
Text Version: ETD
Appears in Collections:dissertation

Citable URI : http://hdl.handle.net/10069/38323

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