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Prognostic Prediction of Oral Squamous Cell Carcinoma by E-Cadherin and N-Cadherin Expression in Overall Cells in Tumor Nests or Tumor Cells at the Invasive Front


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Title: Prognostic Prediction of Oral Squamous Cell Carcinoma by E-Cadherin and N-Cadherin Expression in Overall Cells in Tumor Nests or Tumor Cells at the Invasive Front
Other Titles: 腫瘍胞巣全体もしくは浸潤先端におけるE-cadherinおよびN-cadherinの発現程度を用いた口腔扁平上皮癌患者の予後予測
Authors: 本田, 由
Authors (alternative): Honda, Yuu
Issue Date: 20-Mar-2018
Publisher: Springer Netherlands
Citation: Nagasaki University (長崎大学), 博士(歯学) (2018-03-20)
Abstract: Epithelial-mesenchymal transition (EMT) is a significant process in the invasion and metastasis of cancers including oral squamous cell carcinoma (OSCC), and the cadherin switch has been identified as one of the hallmarks of EMT. The aim of the present study was to evaluate the significance of the cadherin switch in the prognosis of OSCC and generate a model for prognostic predictions. Seventy-six biopsy and/or initial surgical specimens from OSCC patients were immunohistochemically analyzed for the expression of E-cadherin and N-cadherin in either overall OSCC cells in tumor nests or in OSCC cells at the invasive front. Among 76 OSCC cases, overall OSCC cells in tumor nests were negative for the expression of E-cadherin in 10 cases and positive for that of N-cadherin in 53 cases. Among 10 cases negative for the expression of E-cadherin, 4 cases were positive for that of N-cadherin. In OSCC cells at the invasive front, the expression of E-cadherin was negative in 62 cases, while that of N-cadherin was positive in 39 cases. Among 62 cases negative for the expression of E-cadherin, 33 cases were positive for that of N-cadherin. A logistic regression analysis showed that a model using the evaluation of N-cadherin expression in overall OSCC cells in tumor nests with a cut-off point of 70 years old was the best fit model. These results suggest that N-cadherin has significant value in prognostic predictions for OSCC patients.
Description: 長崎大学学位論文 学位記番号:博(医歯薬)甲第1045号 学位授与年月日:平成30年3月20日 / Author: Yuu Ozaki-Honda, Sachiko Seki, Mutsunori Fujiwara, Masaaki Matsuura, Shuichi Fujita, Hisazumi Ikeda, Masahiro Umeda, Takao Ayuse, Tohru Ikeda / Citation: Cancer Microenvironment, 10(1-3), pp.87–94; 2017
Keywords: Oral squamous cell carcinoma / Cadherin / Epithelial-mesenchymal transition / Multivariate analysis / Prognosis
URI: http://hdl.handle.net/10069/38325
ISSN: 18752292
DOI: 10.1007/s12307-017-0201-1
Relational Links: http://hdl.handle.net/10069/38087
Rights: © Springer Science+Business Media B.V. 2017 / The final publication is available at link.springer.com
Type: Thesis or Dissertation
Text Version: ETD
Appears in Collections:dissertation

Citable URI : http://hdl.handle.net/10069/38325

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