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Effect of pH and Additives on the Compatibility between Vancomycin and Furosemide Injections

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タイトル: Effect of pH and Additives on the Compatibility between Vancomycin and Furosemide Injections
著者: Munakata, Chie / Fuchigami, Yuki / Makizoe, Takayuki / Miura, Yusuke / Yamaoka, Mariko / Sasahara, Satomi / Hata, Katsutomo / Tachiki, Hidehisa / Sasaki, Hitoshi / Hagimori, Masayori / Kawakami, Shigeru
発行日: 2018年 6月 1日
出版者: The Pharmaceutical Society of Japan / 日本薬学会
引用: Yakugaku Zasshi, 138(6), pp.853-860; 2018
抄録: The physicochemical compatibility between injections of different agents is very important. An injection of the antibiotic vancomycin (VCM) is acidic and its standard pH range is 2.5-4.5. In clinical treatments, VCM injections are often used with Lasix® (furosemide) injections. The Lasix® injection is alkaline and its standard pH range is 8.6-9.6. Therefore, mixing VCM injections with Lasix® injections may cause compatibility problems. We evaluated the effect of pH on the compatibility between VCM (original and two generic) and Lasix® injections. Compatibility was not observed in non-pH-adjusted VCM with Lasix® injections, but white crystals appeared when VCM injections adjusted to pH 2.5 experimentally were mixed with a Lasix® injection, suggesting that the acidic condition of VCM injections cause compatibility. However, the residual rates of VCM did not change after 24 h in all mixtures. We analyzed the crystals by mass spectrometry and 1H-NMR, and identified them to comprise furosemide.
キーワード: compatibility / furosemide / generic drug / vancomycin
URI: http://hdl.handle.net/10069/38373
ISSN: 00316903
DOI: 10.1248/yakushi.18-00004
権利: © 2018 The Pharmaceutical Society of Japan.
資料タイプ: Journal Article
原稿種類: publisher
出現コレクション:110 学術雑誌論文

引用URI : http://hdl.handle.net/10069/38373



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