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Peripheral Ulcerative Keratitis Associated with Granulomatosis with Polyangiitis Emerging Despite Cyclophosphamide, Successfully Treated with Rituximab


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タイトル: Peripheral Ulcerative Keratitis Associated with Granulomatosis with Polyangiitis Emerging Despite Cyclophosphamide, Successfully Treated with Rituximab
著者: Fujita, Yuya / Fukui, Shoichi / Endo, Yushiro / Tsuji, Sosuke / Takatani, Ayuko / Shimizu, Toshimasa / Umeda, Masataka / Nishino, Ayako / Koga, Tomohiro / Kawashiri, Shin-ya / Iwamoto, Naoki / Ichinose, Kunihiro / Tamai, Mami / Nakamura, Hideki / Origuchi, Tomoki / Ueki, Ryotaro / Uematsu, Masafumi / Ishida, Kaori / Abe, Kuniko / Kawakami, Atsushi
発行日: 2018年 6月15日
出版者: 日本内科学会 / Japanese Society of Internal Medicine
引用: Internal Medicine57(12), pp.1783-1788; 2018
抄録: A 67-year-old Japanese man was diagnosed with granulomatosis with polyangiitis based on the presence of right maxillary sinusitis, proteinase 3 antineutrophil cytoplasmic antibody positivity, and right scleritis. A conjunctival biopsy specimen showed neutrophil-predominant infiltration around the vessels without granuloma. Because there was a risk of blindness, pulsed methylprednisolone and intravenous cyclophosphamide pulse therapy (IVCY) were started. However, it was ineffective, and peripheral ulcerative keratitis newly emerged. We promptly switched the treatment from IVCY to rituximab, and ophthalmologists performed amniotic membrane transplantation, which avoided blindness. The close and effective working relationship between physicians and ophthalmologists improved our patient’s ocular prognosis.
キーワード: ANCA-associated vasculitis / granulomatosis with polyangiitis / peripheral ulcerative keratitis / rituximab / scleritis / Wegener's granulomatosis
URI: http://hdl.handle.net/10069/38381
ISSN: 09182918
DOI: 10.2169/internalmedicine.0215-17
権利: © 2018 by The Japanese Society of Internal Medicine.
資料タイプ: Journal Article
原稿種類: publisher
出現コレクション:110 学術雑誌論文

引用URI : http://hdl.handle.net/10069/38381

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