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Does Respiratory Virus Coinfection Increases the Clinical Severity of Acute Respiratory Infection Among Children Infected With Respiratory Syncytial Virus?


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タイトル: Does Respiratory Virus Coinfection Increases the Clinical Severity of Acute Respiratory Infection Among Children Infected With Respiratory Syncytial Virus?
その他のタイトル: 呼吸器ウイルス重複感染はRSウイルスによる急性呼吸器感染症小児の臨床的重症度を増悪するか?
著者: 原田, 義髙
著者(別表記) : Harada, Yoshitaka
発行日: 2018年 6月 6日
出版者: Lippincott Williams & Wilkins, Inc.
引用: Nagasaki University (長崎大学), 博士(医学) (2018-06-06)
抄録: Background: Respiratory syncytial virus (RSV) is a leading cause of acute lower respiratory infection in children less than 5 years of age. The impact of non-RSV respiratory virus coinfection on the severity of RSV disease is unknown. Methods: This hospital-based prospective study was conducted in Nagasaki, Japan, on all children less than 5 years of age with acute respiratory infection (ARI) who had undergone a rapid RSV diagnostic test between April 2009 and March 2010. Thirteen respiratory viruses were identified from nasopharyngeal swab samples using a multiplex polymerase chain reaction; polymerase chain reaction–positive samples were considered as confirmed respiratory virus infections. The cases were classified into 3 categories (pneumonia, moderate-to-severe nonpneumonic ARI and mild ARI) according to the findings of the chest radiograph and the hospitalization records. Results: Among 384 cases enrolled, 371 were eligible for analysis, of whom 85 (23%) were classified as pneumonia cases; 137 (37%) as moderate-to-severe nonpneumonic ARI cases and 162 (40%) as mild ARI cases. RSV was detected in 172 cases (61.6%), and 31 cases (18.0%) had double or triple infections with other respiratory viruses. RSV infection was more frequently observed in pneumonia cases (odds ratio [OR]: 2.3; 95% confidence interval [CI]: 1.31–3.9) and moderate-to-severe nonpneumonic ARI cases (OR: 2.95; 95% CI: 1.82–4.78) than in mild ARI cases. The association with moderate-to-severe nonpneumonic ARI cases was stronger with RSV/non-RSV respiratory virus coinfection (adjusted OR: 4.91; 95% CI: 1.9–12.7) than with RSV single infection (adjusted OR: 2.77; 95% CI: 1.64–4.7). Conclusions: Non-RSV respiratory virus coinfection is not uncommon in RSV-infected children and may increase the severity of RSV disease.
記述: 長崎大学学位論文 学位記番号:博(医歯薬)乙第52号 学位授与年月日:平成30年6月6日 / Author: Harada, Y., Kinoshita, F., Yoshida, L.M., Le Nhat, M., Suzuki, M., Morimoto, K., Toku, Y., Tomimasu, K., Moriuchi, H., Ariyoshi, K / Citation: The Pediatric Infectious Disease Journal, 32(5), pp.441-445; 2013
キーワード: acute respiratory infections / viral coinfection / respiratory virus / respiratory syncytial virus / reverse transcription-polymerase chain reaction
URI: http://hdl.handle.net/10069/38431
ISSN: 08913668
DOI: 10.1097/INF.0b013e31828ba08c
関連リンク : http://hdl.handle.net/10069/38363
権利: © 2013 Lippincott Williams & Wilkins, Inc. This is a non-final version of an article published in final form in The Pediatric Infectious Disease Journal, 32(5), pp.441-445; 2013.
資料タイプ: Thesis or Dissertation
原稿種類: ETD
出現コレクション:110 学位論文

引用URI : http://hdl.handle.net/10069/38431

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