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In Vitro Activity of Lascufloxacin against Streptococcus pneumoniae with Mutations in the Quinolone Resistance-Determining Regions


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Title: In Vitro Activity of Lascufloxacin against Streptococcus pneumoniae with Mutations in the Quinolone Resistance-Determining Regions
Authors: Murata, Mika / Kosai, Kosuke / Yamauchi, Shunsuke / Sasaki, Daisuke / Kaku, Norihito / Uno, Naoki / Morinaga, Yoshitomo / Hasegawa, Hiroo / Miyazaki, Taiga / Izumikawa, Koichi / Mukae, Hiroshi / Yanagihara, Katsunori
Issue Date: Apr-2018
Publisher: American Society for Microbiology
Citation: Antimicrobial Agents and Chemotherapy, 62(4), 01971-17; 2018
Abstract: Lascufloxacin showed potent activity against Streptococcus pneumoniae with a GyrA or ParC mutation (first-step mutant). The frequency of selecting resistant strains tended to be lower for lascufloxacin than for levofloxacin and garenoxacin after drug exposure in first-step mutants but was similar in the comparison between lascufloxacin and moxifloxacin. The increase in MIC was smaller for lascufloxacin than for levofloxacin, garenoxacin, and moxifloxacin when clinical strains with only ParC mutations were exposed to the corresponding drug.
Keywords: Fluoroquinolone resistance / Lascufloxacin / Streptococcus pneumoniae
URI: http://hdl.handle.net/10069/38449
ISSN: 00664804
DOI: 10.1128/AAC.01971-17
Rights: © Copyright 2018 American Society for Microbiology. All Rights Reserved.
Type: Journal Article
Text Version: author
Appears in Collections:Articles in academic journal

Citable URI : http://hdl.handle.net/10069/38449

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