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Pathological significance and prognostic roles of densities of CD57+ cells, CD68+ cells, and mast cells, and their ratios in clear cell renal cell carcinoma


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タイトル: Pathological significance and prognostic roles of densities of CD57+ cells, CD68+ cells, and mast cells, and their ratios in clear cell renal cell carcinoma
著者: Nakanishi, Hiromi / Miyata, Yasuyoshi / Mochizuki, Yasushi / Yasuda, Takuji / Nakamura, Yuichiro / Araki, Kyohei / Sagara, Yuji / Matsuo, Tomohiro / Ohba, Kojiro / Sakai, Hideki
発行日: 2018年 9月
出版者: Elsevier Inc.
引用: Human Pathology, 79, pp.102-108; 2018
抄録: The immune system is closely associated with malignant behavior in renal cell carcinoma (RCC). Therefore, understanding the pathological roles of immune cells in tumor stroma is essential to discuss the pathological characteristics of RCC. In this study, the clinical significance of densities of CD57+ cells, CD68+ cells, and mast cells, and their ratios were investigated in patients with clear cell RCC. The densities of CD57+, CD68+, and mast cells were evaluated by immunohistochemical techniques in 179 patients. Proliferation index, apoptotic index, and microvessel density were evaluated by using anti–Ki-67, anti–cleaved caspase-3, and anti-CD31 antibodies, respectively. The density of CD57+ cell was negatively correlated with grade, pT stage, and metastasis, although densities of CD68+ cell and mast cell were positively correlated. Ratios of CD68+ cell/CD57+ cell and mast cell/CD57+ cell were significantly correlated with grade, pT stage, and metastasis. Survival analyses showed that the CD68+ cell/CD57+ cell ratio was a significant predictor for cause-specific survival by multivariate analyses (hazard ratio = 1.41, 95% confidence interval = 1.03-1.93, P =.031) and was significantly correlated with proliferation index, apoptotic index, and microvessel density (r =.47, P <. 001; r = −.31, P <.001; and r =.40, P <.001, respectively). In conclusion, CD57+ cells, CD68+ cells, and mast cells played important roles in malignancy in clear cell RCC. The CD68+ cell/CD57+ cell ratio was strongly correlated with pathological features and prognosis in these patients because this ratio reflected the status of cancer cell proliferation, apoptosis, and angiogenesis.
キーワード: CD57+ cell / CD68+ cell / Mast cell / Prognosis / Renal cell carcinoma
URI: http://hdl.handle.net/10069/38532
ISSN: 00468177
DOI: 10.1016/j.humpath.2018.05.007
権利: © 2018 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)
資料タイプ: Journal Article
原稿種類: publisher
出現コレクション:130 学術雑誌論文

引用URI : http://hdl.handle.net/10069/38532

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