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Association between atherosclerosis and handgrip strength in non-hypertensive populations in India and Japan


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Title: Association between atherosclerosis and handgrip strength in non-hypertensive populations in India and Japan
Authors: Yamanashi, Hirotomo / Kulkarni, Bharati / Edwards, Tansy / Kinra, Sanjay / Koyamatsu, Jun / Nagayoshi, Mako / Shimizu, Yuji / Maeda, Takahiro / Cox, Sharon E
Issue Date: Jul-2018
Publisher: 日本老年医学会
Citation: Geriatrics and Gerontology International, 18(7), pp.1071-1078; 2018
Abstract: Aim: Although several risk factors contribute to the development of sarcopenia, whether preclinical atherosclerosis contributes to the risk of sarcopenia is not established. The present cross-sectional study aimed to investigate if there is an association between preclinical atherosclerosis and muscle strength among two ethnic populations. Methods: Participants included individuals aged ≥40 years and enrolled in the third follow-up examination of the Andhra Pradesh Children and Parents Study, India, and in the baseline assessments of the Nagasaki Islands Study, Japan. Preclinical atherosclerosis was evaluated by carotid intima-media thickness, brachial-ankle pulse wave velocity, cardio-ankle vascular index. The association of carotid intima-media thickness and pulse wave velocity/cardio-ankle vascular index with handgrip strength (HGS) was analyzed separately in the sexes and for hypertensive status from the two cohorts using a multivariable linear regression model. Results: Data on a total of 1501 participants in India and 3136 participants in Japan were analyzed. Carotid intima-media thickness was negatively associated with HGS in non-hypertensive Indian men (B coefficient = −5.38, P = 0.036). Arterial stiffness was also associated with HGS in non-hypertensive Indian men (B = −0.97, P = 0.001), but not in hypertensive Indian men. Same as Indian men, we found the significant associations between arterial stiffness and HGS in non-hypertensive women in both India and Japan (B = −0.44, P = 0.020, B = −0.63, P = 0.016, respectively), but not in hypertensive women. Conclusions: The negative association between preclinical atherosclerosis and HGS was dominantly found in non-hypertensive participants.
Keywords: atherosclerosis / carotid intima-media thickness / handgrip strength / pulse wave velocity, sarcopenia
URI: http://hdl.handle.net/10069/38538
ISSN: 14441586
DOI: 10.1111/ggi.13312
Rights: © 2018 The Authors Geriatrics & Gerontology International published by John Wiley & Sons Australia, Ltd on behalf of Japan Geriatrics Society. This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
Type: Journal Article
Text Version: publisher
Appears in Collections:Articles in academic journal

Citable URI : http://hdl.handle.net/10069/38538

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