DSpace university logo mark
Japanese | English 

NAOSITE : Nagasaki University's Academic Output SITE > 120 熱帯医学研究所 > 120 学術雑誌論文 >

BST-2 controls T cell proliferation and exhaustion by shaping the early distribution of a persistent viral infection

ファイル 記述 サイズフォーマット
PLosPat14_1007172.pdf17.27 MBAdobe PDF本文ファイル

タイトル: BST-2 controls T cell proliferation and exhaustion by shaping the early distribution of a persistent viral infection
著者: Urata, Shuzo / Kenyon, Elizabeth / Nayak, Debasis / Cubitt, Beatrice / Kurosaki, Yohei / Yasuda, Jiro / de la Torre, Juan C. / McGavern, Dorian B.
発行日: 2018年 7月20日
出版者: Public Library of Science
引用: PLoS Pathogens, 14(7), art. no. e1007172; 2018
抄録: The interferon inducible protein, BST-2 (or, tetherin), plays an important role in the innate antiviral defense system by inhibiting the release of many enveloped viruses. Consequently, viruses have evolved strategies to counteract the anti-viral activity of this protein. While the mechanisms by which BST-2 prevents viral dissemination have been defined, less is known about how this protein shapes the early viral distribution and immunological defense against pathogens during the establishment of persistence. Using the lymphocytic choriomeningitis virus (LCMV) model of infection, we sought insights into how the in vitro antiviral activity of this protein compared to the immunological defense mounted in vivo. We observed that BST-2 modestly reduced production of virion particles from cultured cells, which was associated with the ability of BST-2 to interfere with the virus budding process mediated by the LCMV Z protein. Moreover, LCMV does not encode a BST-2 antagonist, and viral propagation was not significantly restricted in cells that constitutively expressed BST-2. In contrast to this very modest effect in cultured cells, BST-2 played a crucial role in controlling LCMV in vivo. In BST-2 deficient mice, a persistent strain of LCMV was no longer confined to the splenic marginal zone at early times post-infection, which resulted in an altered distribution of LCMV-specific T cells, reduced T cell proliferation / function, delayed viral control in the serum, and persistence in the brain. These data demonstrate that BST-2 is important in shaping the anatomical distribution and adaptive immune response against a persistent viral infection in vivo.
URI: http://hdl.handle.net/10069/38557
ISSN: 15537366
DOI: 10.1371/journal.ppat.1007172
権利: This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication.
資料タイプ: Journal Article
原稿種類: publisher
出現コレクション:120 学術雑誌論文

引用URI : http://hdl.handle.net/10069/38557



Valid XHTML 1.0! Copyright © 2006-2015 長崎大学附属図書館 - お問い合わせ Powerd by DSpace