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Enhancement of antibacterial effect of quaternary ammonium with inorganic nanosheets against Enterobacter cloacae

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タイトル: Enhancement of antibacterial effect of quaternary ammonium with inorganic nanosheets against Enterobacter cloacae
著者: Yoshida, Eri / Lawn, Murray / Nagayasu, Takeshi / Kamada, Kai
発行日: 2018年 7月19日
出版者: Springer Netherlands
引用: Journal of Nanoparticle Research, 20(7), art.no.199; 2018
抄録: To suppress nosocomial infections, numerous studies of quaternary ammonium cations (R4N+) to improve the antibiotic properties have been investigated. However, most of them reported developments of novel organic or polymeric materials with R4N+. To pioneer antibacterial inorganic materials hybridized with R4N+, a colloidal solution of metal oxide nanosheets, which have a small particle size (typically less than 10 nm), is considered to be a suitable option because oxide nanosheets with a negative surface charge strongly interact R4N+. Herein, we demonstrate for the first time that the high antibacterial/bactericidal effects of titanate nanosheets (TNS) adsorbing tetramethylammonium (TMA-TNS) or tetrabultylammonium ions (TBA-TNS). Their antibacterial effects against Enterobacter cloacae were evaluated using a colony forming unit (CFU) counting method. The results showed that the synthesized TNS composites had superior antibacterial and bactericidal effects to those of free R4N+ and TBA-TNS exhibited the strongest effect (69% CFU reduction compared with that of free TBA+ and 98% CFU reduction compared with the control) among the samples examined. Dark incubation was employed to ensure that photocatalytic reaction of semiconducting TNS did not contribute to the process. Compared with TiO2 spherical particles, such high bactericidal effect would be induced by a synergistic function of TBA+ and TNS, which physically damages bacteria due to long hydrophobic alkyl chains and an anisotropic nanocrystalline structure with sharp edges, respectively.
キーワード: Antibacterial / Bactericidal / Colloids / Enterobacter cloacae / Quaternary ammonium compounds / Titanate nanosheets
URI: http://hdl.handle.net/10069/38565
ISSN: 13880764
DOI: 10.1007/s11051-018-4303-6
権利: © 2018, Springer Nature B.V. The final publication is available at link.springer.com
資料タイプ: Journal Article
原稿種類: author
出現コレクション:060 学術雑誌論文

引用URI : http://hdl.handle.net/10069/38565



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