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Distribution of dipeptidyl peptidase (DPP) 4, DPP5, DPP7, and DPP11 in human oral microbiota – potent biomarkers indicating presence of periodontopathic bacteria

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タイトル: Distribution of dipeptidyl peptidase (DPP) 4, DPP5, DPP7, and DPP11 in human oral microbiota – potent biomarkers indicating presence of periodontopathic bacteria
著者: Ohara-Nemoto, Yuko / Shimoyama, Yu / Nakasato, Manami / Nishimata, Haruka / Ishikawa, Taichi / Sasaki, Minoru / Kimura, Shigenobu / Nemoto, Takayuki K
発行日: 2018年 9月10日
出版者: Oxford University Press
引用: FEMS Microbiology Letters, Article in Press
抄録: Dipeptidyl peptidase (DPP) 4, DPP5, DPP7, and DPP11, expressed in the periplasmic space, are crucial for energy production for Porphyromonas gingivalis, an asaccharolytic bacterium that causes periodontal disease. Bacterial DPP4 seems to be involved in regulation of blood glucose level via degradation of incretins. The present study aimed to identify four dpp orthologs in oral microbiota by database searches, and their enzymatic activities in periodontopathic and cariogenic bacteria, as well as oral specimens were determined. Search in the databases suggested that 43 species of 772 taxa possess dpp4 and other dpp genes. Most species are in the genera Bacteroides, Capnocytophaga, Porphyromonas, Prevotella, and Tannerella, indicating a limited distribution of dpp orthologs in anaerobic periodontopathic rods. In accordance with those results, activities of all four DPPs were demonstrated in P. gingivalis, Porphyromonas endodontalis, and Tannerella forsythia, while they were negligible in Treponema denticola, Fusobacterium nucleatum, and Aggregatibacter actinomycetemcomitans. Furthermore, DPP activities were also detected in subgingival dental plaque at different intensities among individual specimens, while DPP4 activity presumably derived from human entity was solely predominant in saliva samples. These findings demonstrated that DPP activities in dental plaque serve as potent biomarkers to indicate the presence of periodontopathic bacteria
キーワード: dental plaque / dipeptidyl peptidase / periodontopathic bacteria / Porphyromonas gingivalis / saliva
URI: http://hdl.handle.net/10069/38571
ISSN: 03781097
DOI: 10.1093/femsle/fny221
権利: © FEMS 2018. This is a pre-copyedited, author-produced version of an article accepted for publication in FEMS Microbiology Letters following peer review. The version of record FEMS Microbiology Letters, fny221 is available online at: https://doi.org/10.1093/femsle/fny221.
資料タイプ: Journal Article
原稿種類: author
出現コレクション:040 学術雑誌論文

引用URI : http://hdl.handle.net/10069/38571



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