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Adipose-derived mesenchymal stem cells attenuate rejection in a rat lung transplantation model

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タイトル: Adipose-derived mesenchymal stem cells attenuate rejection in a rat lung transplantation model
その他のタイトル: 脂肪由来間葉系幹細胞はラット肺移植モデルにおいて拒絶を抑制する
著者: 渡邉, 洋之助
著者(別表記) : Watanabe, Hironosuke
発行日: 2018年 9月 5日
出版者: Elsevier Inc.
引用: Nagasaki University (長崎大学), 博士(医学) (2018-09-05)
抄録: Background: Immunosuppression following lung transplantation is a key aspect to the graft's survival. However, the well-known complications that are caused by immunosuppressive regimens present an opportunity to study ways to minimize the usage of these drugs. Recently, a promising discovery has been made pertaining to the immunomodulatory effects of adipose tissue–derived mesenchymal stem cells (ADMSCs) through their secretion of hepatocyte growth factor. In the hopes of mitigating the adverse effects of standard immunosuppressive regimens, our study aims to investigate the effects of ADMSCs on the immune response utilizing a rat lung transplantation model. Methods: Each rat's own ADMSCs were intravenously administered immediately after orthotopic left lung transplantation. The experimental subjects were divided into four groups: 1) control group (group C) was administered no treatment following transplantation; 2) ADMSC group (group A), administered a single intravenous injection of ADMSCs following transplantation; 3) tacrolimus group (group T), administered tacrolimus (0.5 mg/kg) every 24 h following transplantation; and 4) ADMSC and tacrolimus group (AT group) administered a single intravenous injection of ADMSCs in combination with tacrolimus every 24 h following transplantation. Results: The histologically proven rejection grade in group AT was significantly lower than that in group T. The serum levels of hepatocyte growth factor and the expression of cMet in group AT accompanied by low CD40 expression were also significantly higher than those of the lung grafts of group T. Conclusions: These results suggest that co-administration of ADMSCs with tacrolimus is a beneficial therapeutic approach in lung transplantation.
記述: 長崎大学学位論文 学位記番号:博(医歯薬)甲第1089号 学位授与年月日:平成30年9月5日 / Author: Hironosuke Watanabe, Tomoshi Tsuchiya, Koichiro Shimoyama, Akira Shimizu, Sadanori Akita, Hiroshi Yukawa, Yoshinobu Baba, and Takeshi Nagayasu / Citation: Journal of Surgical Research, 227, pp.17-27; 2018
キーワード: Adipose tissue–derived mesenchymal stem cell / Lung transplantation / Hepatocyte growth factor
URI: http://hdl.handle.net/10069/38576
ISSN: 00224804
DOI: 10.1016/j.jss.2018.01.016
権利: © 2018 Elsevier Inc. All rights reserved.
資料タイプ: Thesis or Dissertation
原稿種類: ETD
出現コレクション:110 学位論文

引用URI : http://hdl.handle.net/10069/38576



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