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Serum exosomal microRNA‑122 and microRNA‑21 as predictive biomarkers in transarterial chemoembolization‑treated hepatocellular carcinoma patients


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タイトル: Serum exosomal microRNA‑122 and microRNA‑21 as predictive biomarkers in transarterial chemoembolization‑treated hepatocellular carcinoma patients
その他のタイトル: 経動脈的化学塞栓術を行った肝細胞癌患者のバイオマーカーとしての血清中のexosomal microRNA-122およびmicroRNA-21の意義
著者: 末廣, 智之
著者(別表記) : Suehiro, Tomoyuki
発行日: 2018年 9月 5日
出版者: Spandidos Publications
引用: Nagasaki University (長崎大学), 博士(医学) (2018-09-05)
抄録: Exosomal microRNAs (miRNAs) have been investigated as potential novel biomarkers, and miR‑122 and miR‑21 were shown to be important in hepatocellular carcinoma (HCC). We analyzed the importance of serum exosomal miRNA expression levels in HCC patients that underwent transarterial chemoembolization (TACE). Seventy‑five HCC patients who underwent TACE as the initial treatment in Nagasaki University Hospital were enrolled. Exosomal miRNAs were isolated from serum samples collected before and after TACE. Exosomal miR‑122 expression levels significantly decreased after TACE (P=0.012), while the exosomal miR‑21 expression levels did not significantly change. The expression levels of exosomal miR‑122 before TACE were shown to correlate significantly with aspartate aminotransferase (r=0.31, P=0.004) and alanine aminotransferase (r=0.33, P=0.003) levels, tumor diameter (r=0.29, P=0.010) and Child‑Pugh score (r=‑0.28, P=0.013). The median survival time for all patients was 47 months, and neither of the investigated exosomal miRNAs were shown to be independent factors associated with the disease‑specific survival. According to the median relative expression of miR‑122 after TACE/before TACE (miR‑122 ratio) in liver cirrhosis patients (n=57), the patients with a higher miR‑122 ratio had significantly longer disease‑specific survival, compared with that of the patients with the lower miR‑122 ratio (P=0.0461). Multivariate Cox proportional hazards regression analysis of clinical parameters revealed that a lower exosomal miR‑122 ratio (HR 2.720; 95% confidence interval, 1.035‑8.022; P=0.042) is associated with the disease‑specific survival. Taken together, our results demonstrate that the exosomal miR‑122 level alterations may represent a predictive biomarker in HCC patients with liver cirrhosis treated with TACE.
記述: 長崎大学学位論文 学位記番号:博(医歯薬)甲第1091号 学位授与年月日:平成30年9月5日 / Author: Tomoyuki Suehiro, Hisamitsu Miyaaki, Yasuko Kanda, Hidetaka Shibata, Takuya Honda, Eisuke Ozawa, Satoshi Miuma, Naota Taura, Kazuhiko Nakao / Citation: Oncology Letters, 16(3), pp.3267-3273; 2018
キーワード: carcinoma / hepatocellular / chemoembolization / therapeutic / exosome / microRNA
URI: http://hdl.handle.net/10069/38578
ISSN: 17921074
DOI: 10.3892/ol.2018.8991
権利: © 2018, Spandidos Publications
資料タイプ: Thesis or Dissertation
原稿種類: ETD
出現コレクション:110 学位論文

引用URI : http://hdl.handle.net/10069/38578

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