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Epidemiology and Clinical Features of Pulmonary Nontuberculous Mycobacteriosis in Nagasaki, Japan


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タイトル: Epidemiology and Clinical Features of Pulmonary Nontuberculous Mycobacteriosis in Nagasaki, Japan
その他のタイトル: 長崎県における肺非結核性抗酸菌症の疫学および臨床的特徴
著者: 井手, 昇太郎
著者(別表記) : Ide, Shotaro
発行日: 2018年 9月 5日
出版者: Public Library of Science
引用: Nagasaki University (長崎大学), 博士(医学) (2018-09-05)
抄録: Background and Objectives: Recent reports indicate that the incidence of nontuberculous mycobacterial-lung disease (NTM-LD) is increasing. This study aimed to investigate the epidemiology and clinical features of NTM-LD patients in Nagasaki prefecture, Japan to identify the negative prognostic factors for NTM-LD in Japan. Methods: The medical records of patients newly diagnosed with NTM-LD in eleven hospitals in Nagasaki prefecture between January 2001 and February 2010 were reviewed. Data regarding the annual population of each region and the incidence of all forms of tuberculosis were collected to assess geographic variations in NTM-LD incidence, isolates, and radiological features. Results: A total 975 patients were diagnosed with NTM-LD. The incidence increased over the study period and reached 11.0 and 10.1 per 100,000 population in 2008 and 2009, respectively. M. intracellulare was the most common pathogen in the southern region, and M. avium most common in other regions. The most common radiographic pattern was the nodular-bronchiectatic pattern. Age >60 years, body mass index <18.5 kg/m2, underlying lung disease, and cavitary pattern were the negative prognostic factors at the 1-year follow-up. Conclusions: The incidence of NTM-LD has been increasing in Nagasaki prefecture. The isolates and radiographic features of patients vary markedly by region.
記述: 長崎大学学位論文 学位記番号:博(医歯薬)甲第1092号 学位授与年月日:平成30年9月5日 / Author: Shotaro Ide, Shigeki Nakamura, Yoshihiro Yamamoto, Yoshihisa Kohno, Yuichi Fukuda, Hideki Ikeda, Eisuke Sasaki, Katsunori Yanagihara, Yasuhito Higashiyama, Kohji Hashiguchi, Yoji Futsuki, Yuichi Inoue, Kiyoyasu Fukushima, Naofumi Suyama, Shigeru Kohno / Citation: PLOS ONE, 10(5), e0128304; 2015
URI: http://hdl.handle.net/10069/38579
DOI: 10.1371/journal.pone.0128304
権利: © 2015 Ide et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
資料タイプ: Thesis or Dissertation
原稿種類: ETD
出現コレクション:110 学位論文

引用URI : http://hdl.handle.net/10069/38579

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