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Phylogenetic uniqueness of Mycobacterium avium subspecies hominissuis isolated from an abnormal pulmonary bovine case

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タイトル: Phylogenetic uniqueness of Mycobacterium avium subspecies hominissuis isolated from an abnormal pulmonary bovine case
その他のタイトル: 牛肺感染症を引き起こしたマイコバクテリウム・アビウム・ホミニシウスMycobacterium avium subspecies hominissuisの遺伝系統
著者: 吉田, 志緒美
著者(別表記) : Yoshida, Shiomi
発行日: 2018年 9月 5日
出版者: Elsevier B.V.
引用: Nagasaki University (長崎大学), 博士(医学) (2018-09-05)
抄録: Mycobacterium avium subspecies hominissuis (MAH) is an important cause of infection in human pulmonary and swine intestinal cases. Although MAH is isolated from environmental sources frequently, infections of other animals have rarely been analysed. Recently, we detected granulomatous inflammation in bovine lung as an abnormal postmortem inspection case. To ascertain its genetic profile, we conducted a variable numbers of tandem repeats (VNTR) analysis and genomic characterization using deep sequencing. The VNTR type was a unique profile that differed from reported genotypes, but it was assigned within a broad genotypic complex of isolates from human patients and bathrooms. Genomic comparison with 116 registered genome sequences of the subspecies revealed that the strain was separate from five major genetic population groups proposed previously. Although the infection source remains unclear, its isolation from various resources such as animal infection cases should be elucidated more extensively to reveal its genetic diversity and ecological context.
記述: 長崎大学学位論文 学位記番号:博(医歯薬)甲第1095号 学位授与年月日:平成30年9月5日 / Author: Shiomi Yoshida, Tsubasa Araki, Tomohito Asai, Kazunari Tsuyuguchi, Kentaro Arikawa, Tomotada Iwamoto, Chie Nakajima, Yasuhiko Suzuki, Kenji Ohya, Tokuma Yanai, Takayuki Wada, Taro Yamamoto / Citation: Infection, Genetics and Evolution, 62, pp.122-129; 2018
キーワード: Mycobacterium avium subspecies hominissuis / VNTR / Genomic comparison
URI: http://hdl.handle.net/10069/38584
ISSN: 15671348
DOI: 10.1016/j.meegid.2018.04.013
権利: © 2018 Elsevier B.V. All rights reserved.
資料タイプ: Thesis or Dissertation
原稿種類: ETD
出現コレクション:110 学位論文

引用URI : http://hdl.handle.net/10069/38584



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