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Intestinal fatty acid–binding protein levels in patients with chronic renal failure

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タイトル: Intestinal fatty acid–binding protein levels in patients with chronic renal failure
その他のタイトル: 慢性腎不全患者における血中腸型脂肪酸結合蛋白濃度に関する検討
著者: 岡田, 恭子
著者(別表記) : Okada, Kyoko
発行日: 2018年 9月 5日
出版者: Elsevier Inc.
引用: Nagasaki University (長崎大学), 博士(医学) (2018-09-05)
抄録: Background: Intestinal fatty acid–binding protein (I-FABP), a biomarker of enterocyte injury, has been reported to be a diagnostic marker of intestinal ischemia and a prognostic marker in critically ill patients. However, the kinetics of I-FABP in renal failure patients is unknown. We sought to identify I-FABP levels in patients with chronic kidney disease (CKD) and end-stage kidney disease (ESKD) on hemodialysis (HD) and to identify the manner in which the I-FABP levels change. Materials and methods: Adult patients who were admitted for elective cardiac surgery with either normal renal function (NRF), CKD, or ESKD on HD were enrolled. Serum I-FABP levels in NRF and CKD patients and in ESKD patients before and after HD were determined. Results: A total of 124 patients were evaluated: 47 NRF, 53 CKD, and 24 ESKD. The I-FABP levels of the CKD patients and pre-HD ESKD patients were significantly higher than those of the NRF patients (P = 0.018 and P <0.001, respectively). I-FABP levels were significantly negatively correlated with the estimated glomerular filtration rate in NRF and CKD patients (Spearman's ρ = −0.313, P = 0.002). In addition, I-FABP levels in ESKD patients were significantly lower after HD than those before HD (P <0.001). Conclusions: I-FABP levels in CKD and pre-HD ESKD patients were significantly higher than those in NRF patients. In addition, I-FABP was significantly eliminated by HD in patients with ESKD. Clinicians and researchers should consider this aspect of I-FABP when using it as a diagnostic and prognostic marker in patients with renal insufficiency.
記述: 長崎大学学位論文 学位記番号:博(医歯薬)乙第53号 学位授与年月日:平成30年9月5日
キーワード: Biomarker / Critically ill patients / Enterocyte / Glomerular filtration rate / Intestinal ischemia / Renal insufficiency
URI: http://hdl.handle.net/10069/38590
ISSN: 00224804
DOI: 10.1016/j.jss.2018.04.057
権利: © 2018 Elsevier Inc. All rights reserved.
資料タイプ: Thesis or Dissertation
原稿種類: ETD
出現コレクション:110 学位論文

引用URI : http://hdl.handle.net/10069/38590



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