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Antiviral Activity of Peanut (Arachis hypogaea L.) Skin Extract Against Human Influenza Viruses

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タイトル: Antiviral Activity of Peanut (Arachis hypogaea L.) Skin Extract Against Human Influenza Viruses
著者: Makau, Juliann Nzembi / Watanabe, Ken / Mohammed, Magdy M.D. / Nishida, Noriyuki
発行日: 2018年 8月
出版者: Mary Ann Liebert Inc.
引用: Journal of Medicinal Food, 21(8), pp.777-784; 2018
抄録: The high propensity of influenza viruses to develop resistance to antiviral drugs necessitates the continuing search for new therapeutics. Peanut skins, which are low-value byproducts of the peanut industry, are known to contain high levels of polyphenols. In this study, we investigated the antiviral activity of ethanol extracts of peanut skins against various influenza viruses using cell-based assays. Extracts with a higher polyphenol content exhibited higher antiviral activities, suggesting that the active components are the polyphenols. An extract prepared from roasted peanut skins effectively inhibited the replication of influenza virus A/WSN/33 with a half maximal inhibitory concentration of 1.3 μg/mL. Plaque assay results suggested that the extract inhibits the early replication stages of the influenza virus. It demonstrated activity against both influenza type A and type B viruses. Notably, the extract exhibited a potent activity against a clinical isolate of the 2009 H1N1 pandemic, which had reduced sensitivity to oseltamivir. Moreover, a combination of peanut skin extract with the anti-influenza drugs, oseltamivir and amantadine, synergistically increased their antiviral activity. These data demonstrate the potential application of peanut skin extract in the development of new therapeutic options for influenza management.
キーワード: anti-influenza activity / drug resistance / functional foods / natural products / polyphenols
URI: http://hdl.handle.net/10069/38593
ISSN: 1096620X
DOI: 10.1089/jmf.2017.4121
権利: © 2018, Mary Ann Liebert,Inc. and Korean Society of Food Science and Nutrition. Final publication is available from Mary Ann Liebert,Inc., publishers http://dx.doi.org/10.1089/jmf.2017.4121
資料タイプ: Journal Article
原稿種類: author
出現コレクション:110 学術雑誌論文

引用URI : http://hdl.handle.net/10069/38593



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