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GALT carcinoma: three case reports with glycoprotein 2 immunohistochemistry and electron microscopic observations


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タイトル: GALT carcinoma: three case reports with glycoprotein 2 immunohistochemistry and electron microscopic observations
著者: Hayashi, Hiroko / Ohtani, Masashi / Sada, Yuki / Iwasaki, Keisuke / Shimokawa, Isao
発行日: 2018年 4月24日
出版者: John Wiley & Sons Ltd.
引用: Histopathology, 73(3), pp.521-528; 2018
抄録: Aims: Gut-associated lymphoid tissue (GALT) carcinoma is a rare colorectal tumour that arises in the epithelium covering GALT. GALT carcinoma is a differentiated tubular adenocarcinoma with dense lymphoid tissue with a characteristically well-demarcated margin. To date, 26 cases of GALT carcinoma, including the three cases discussed here, have been reported. Most (24 of 26) were discovered at early stages and none of the cases have documented any metastases. This suggests that GALT carcinoma may have a favourable prognosis. It is hypothesised that GALT carcinoma originates from M cells in specialised epithelia covering GALT. However, this hypothesis has yet to be confirmed. Methods and results: In this study, we examined three cases of GALT carcinoma by immunohistochemistry detection of glycoprotein 2, a specific marker for M cells, and electron microscopy. Our findings showed that the tumour cells of GALT carcinoma in all three cases were negative for M cells. We thus concluded that GALT carcinoma may be a tubular adenocarcinoma arising by chance in the GALT. This unique carcinoma is a diferentiated adenocarcinoma that grows slowly with the development of GALT. Conclusions: We propose that GALT carcinoma should be classified separately because of its histological setting and good prognosis.
キーワード: adenocarcinoma / colon / glycoprotein / gut-associated lymphoid tissue / M cell
URI: http://hdl.handle.net/10069/38612
ISSN: 03090167
DOI: 10.1111/his.13639
権利: © 2018 John Wiley & Sons Ltd. This is the peer reviewed version of the following article: Histopathology, 73(3), pp.521-528; 2018 , which has been published in final form at doi.org/10.1111/his.13639. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.
資料タイプ: Journal Article
原稿種類: author
出現コレクション:110 学術雑誌論文

引用URI : http://hdl.handle.net/10069/38612

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