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Pulmonary Alveolar Proteinosis with Ulcerative Colitis


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Title: Pulmonary Alveolar Proteinosis with Ulcerative Colitis
Authors: Sakamoto, Noriho / Nakashima, Shota / Ishimoto, Hiroshi / Kakugawa, Tomoyuki / Hara, Atsuko / Yura, Hirokazu / Miyamura, Takuto / Nakamichi, Seiko / Obase, Yasushi / Ishimatsu, Yuji / Mukae, Hiroshi
Issue Date: 15-Sep-2018
Publisher: 日本内科学会 / Japanese Society of Internal Medicine
Citation: Internal Medicine, 57(18), pp.2705-2708; 2018
Abstract: A 65-year-old Japanese man was referred to our hospital for the further assessment of cough and dyspnea. He had a history of ulcerative colitis for which he was receiving treatment. Chest computed tomography showed a crazy-paving pattern. His bronchoalveolar lavage fluid had a milky appearance, and a transbronchial lung biopsy specimen revealed acellular periodic acid-Schiff stain-positive bodies. The serum anti-granulocyte macrophage-colony stimulating factor (GM-CSF) antibody titer was elevated. The diagnosis was autoimmune pulmonary alveolar proteinosis (PAP). There are few reports of autoimmune PAP in patients with ulcerative colitis. Some reports suggest that PAP and inflammatory bowel disease might have a common pathogenesis involving the anti-GM-CSF antibody.
Keywords: Anti-GM-CSF antibody / Crohn’s disease / Inflammatory bowel disease
URI: http://hdl.handle.net/10069/38621
ISSN: 09182918
DOI: 10.2169/internalmedicine.0555-17
Rights: Ⓒ 2018 The Japanese Society of Internal Medicine. The Internal Medicine is an Open Access article distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
Type: Journal Article
Text Version: publisher
Appears in Collections:Articles in academic journal

Citable URI : http://hdl.handle.net/10069/38621

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