DSpace university logo mark
詳細検索
Japanese | English 

NAOSITE : Nagasaki University's Academic Output SITE > 130 病院 > 130 学術雑誌論文 >

Minute ventilation-to-carbon dioxide slope is associated with postoperative survival after anatomical lung resection


ファイル 記述 サイズフォーマット
LC125_218.pdf284.32 kBAdobe PDF公開予定日: 2019-12-01

タイトル: Minute ventilation-to-carbon dioxide slope is associated with postoperative survival after anatomical lung resection
著者: Miyazaki, Takuro / Callister, Matthew E.J. / Franks, Kevin / Dinesh, Padma / Nagayasu, Takeshi / Brunelli, Alessandro
発行日: 2018年11月
出版者: Elsevier B.V.
引用: Lung Cancer, 125, pp. 218-222; 2018
抄録: Objectives: The aim of the study was to identify whether ventilation-to-carbon dioxide output (VE/V CO2) slope obtained from cardiopulmonary exercise test (CPET) as part of the preoperative functional workup was an independent prognostic factor for short and long-term survival after major lung resection. Patients and methods: 974 consecutive patients undergoing lobectomy (n = 887) or segmentectomy (n = 87) between April 2014 to March 2018 were included. 209 (22%) underwent CPET, and pulmonary function tests and several clinical factors including age, sex, performance status and comorbidities were retrospectively investigated to identify the prognostic factors with a multivariable Cox regression analysis. Results: Among the patients with measured VE/V CO2, the incidence of cardiopulmonary complications in patients with high VE/V CO2 slope (>40) was 37% (19 of 51) vs. 27% (33 of 121) in those with lower slope values (p = 0.19). The 90-day mortality in patients with high VE/V CO2 slope (n = 8) was 16% vs. 5% (n = 6) in those with lower slope values (p = 0.03). No overall difference in 2-year mortality was identified between the two groups (VE/VCO2 > 40: 70% (54–80) vs. VE/VCO2 ≤ 40: 72% (63–80), log-rank test, p = 0.39). In a Cox regression analysis VE/VCO2 values were associated with poorer 2-year survival (HR 1.05, 95% CI 1.01–1.10, p = 0.030). Conclusions: We found that VE/V CO2 slope was an independent prognostic factor for the 90-day mortality and 2-year survival after anatomic pulmonary resection. This finding may assist during the multidisciplinary treatment decision-making process in high-risk patients with lung cancer.
キーワード: Cardiopulmonary exercise test / Lung cancer / Surgery
URI: http://hdl.handle.net/10069/38678
ISSN: 01695002
DOI: 10.1016/j.lungcan.2018.10.003
権利: (C)2018, Elsevier. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
資料タイプ: Journal Article
原稿種類: author
出現コレクション:130 学術雑誌論文

引用URI : http://hdl.handle.net/10069/38678

このリポジトリに保管されている文献はすべて著作権により保護されています。
印刷やダウンロード等データの複製は、調査研究・教育または学習を目的とする場合に限定されます。

 

Valid XHTML 1.0! Copyright © 2006-2015 長崎大学附属図書館 - お問い合わせ Powerd by DSpace