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一包化調剤後の酸化マグネシウム錠の保管に対する乾燥剤の有無が安定性に与える影響


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Title: 一包化調剤後の酸化マグネシウム錠の保管に対する乾燥剤の有無が安定性に与える影響
Other Titles: Influence of Storage Conditions after One-dose Packaging on Stability of Magnesium Oxide Tablets
Authors: Sato, Kayoko / Inaoka, Natsuko / Kodama, Yukinobu / Muro, Takahiro / Nakamura, Tadahiro / Sasaki, Hitoshi / Kitahara, Takashi
Issue Date: 1-Nov-2018
Publisher: 日本薬学会 / Pharmaceutical Society of Japan
Citation: YAKUGAKU ZASSHI, 138(11): 1435-1441
Abstract: The intestinal motor function declines in the elderly. Many patients have constipation and ingest magnesium oxide for a prolonged period. One-dose packaging of drugs is adopted for many elderly patients to help them to avoid forgetting to take an increase in the number of oral drugs to be taken and improve convenience. Several studies on differences in stability among magnesium oxide preparations including generic drugs have been reported, but no study on the influence of the storage conditions after one-dose packaging on the properties of magnesium oxide tablets has been reported. Three types of magnesium oxide tablet were one-dose-packaged and stored for 12 weeks with and without a desiccant. The difference in hardness and weight significantly increased in all tablets stored without a desiccant. The disintegration time significantly extended in the tablets stored without a desiccant from 2 weeks after the initiation of storage and that of the B tablet markedly extended. However, all tablets passed the disintegration criteria of the disintegration test. The pH-area under the concentration-time curve significantly decreased in the tablets stored without a desiccant. It was suggested that when the one-dose-packaged magnesium oxide preparation is stored, it should be placed in a bag containing a desiccant.
Keywords: magnesium oxide tablet / one-dose packaging / stability
URI: http://hdl.handle.net/10069/38699
ISSN: 00316903
DOI: 10.1248/yakushi.18-00024
Rights: © 2018 The Pharmaceutical Society of Japan
Type: Journal Article
Text Version: publisher
Appears in Collections:Articles in academic journal

Citable URI : http://hdl.handle.net/10069/38699

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