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一包化調剤後の酸化マグネシウム錠の保管に対する乾燥剤の有無が安定性に与える影響


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タイトル: 一包化調剤後の酸化マグネシウム錠の保管に対する乾燥剤の有無が安定性に与える影響
その他のタイトル: Influence of Storage Conditions after One-dose Packaging on Stability of Magnesium Oxide Tablets
著者: Sato, Kayoko / Inaoka, Natsuko / Kodama, Yukinobu / Muro, Takahiro / Nakamura, Tadahiro / Sasaki, Hitoshi / Kitahara, Takashi
発行日: 2018年11月 1日
出版者: 日本薬学会 / Pharmaceutical Society of Japan
引用: YAKUGAKU ZASSHI, 138(11): 1435-1441
抄録: The intestinal motor function declines in the elderly. Many patients have constipation and ingest magnesium oxide for a prolonged period. One-dose packaging of drugs is adopted for many elderly patients to help them to avoid forgetting to take an increase in the number of oral drugs to be taken and improve convenience. Several studies on differences in stability among magnesium oxide preparations including generic drugs have been reported, but no study on the influence of the storage conditions after one-dose packaging on the properties of magnesium oxide tablets has been reported. Three types of magnesium oxide tablet were one-dose-packaged and stored for 12 weeks with and without a desiccant. The difference in hardness and weight significantly increased in all tablets stored without a desiccant. The disintegration time significantly extended in the tablets stored without a desiccant from 2 weeks after the initiation of storage and that of the B tablet markedly extended. However, all tablets passed the disintegration criteria of the disintegration test. The pH-area under the concentration-time curve significantly decreased in the tablets stored without a desiccant. It was suggested that when the one-dose-packaged magnesium oxide preparation is stored, it should be placed in a bag containing a desiccant.
キーワード: magnesium oxide tablet / one-dose packaging / stability
URI: http://hdl.handle.net/10069/38699
ISSN: 00316903
DOI: 10.1248/yakushi.18-00024
権利: © 2018 The Pharmaceutical Society of Japan
資料タイプ: Journal Article
原稿種類: publisher
出現コレクション:130 学術雑誌論文

引用URI : http://hdl.handle.net/10069/38699

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