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Evaluation of miR-122 to Predict High Dose Acetaminophen-Induced Liver Injury in Mice: The Combination Uses of 5-Fluorouracil

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タイトル: Evaluation of miR-122 to Predict High Dose Acetaminophen-Induced Liver Injury in Mice: The Combination Uses of 5-Fluorouracil
著者: Munakata, Chie / Fuchigami, Yuki / Hiroishi, Shu / Haraguchi, Ayana / Hagimori, Masayori / Enomoto, Hatsune / Tachiki, Hidehisa / Kodama, Yukinobu / Sasaki, Hitoshi / Kawakami, Shigeru
発行日: 2018年11月 1日
出版者: 日本薬学会 / Pharmaceutical Society of Japan
引用: Biological & pharmaceutical bulletin, 41(11), pp.1732-1735; 2018
抄録: Administration of high doses of acetaminophen (APAP) is known to cause drug-induced liver injury (DILI) in humans. Therefore, the detection or prediction of these side-effects at an early stage using appropriate biomarkers is the need of the hour. Micro RNA (miR)-122 is expected to be a novel biomarker for liver injury. However, more evidence is required in various alternate situations such as its use in combination as APAP is often used along with anticancer drugs. In the present study, we aimed to evaluate the functions of miR-122 as a biomarker for liver injury in comparison with alanine aminotransferase (ALT) in a mice model with the APAP-induced liver injury (AILI). Consequently, there was a dose-dependent increase in miR-122 after administration of APAP intraperitoneally. Similar observations were made for ALT activity. Additionally, the expression of miR-122 increased in a more rapid manner compared to ALT activity. However, there was a variation in the miR-122 expression. Further, we investigated the drug-drug interaction between APAP and 5-fluorouracil using miR-122 and ALT in mice. As a result, the degree of AILI was not changed by the use of 5-fluorouracil in combination with APAP in mice.
キーワード: Acetaminophen / Biomarker / Liver injury / Micro RNA-122
URI: http://hdl.handle.net/10069/38700
ISSN: 09186158
DOI: 10.1248/bpb.b18-00504
権利: © 2018 The Pharmaceutical Society of Japan
資料タイプ: Journal Article
原稿種類: publisher
出現コレクション:110 学術雑誌論文

引用URI : http://hdl.handle.net/10069/38700



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