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A retrospective study of factors associated with the development of oral candidiasis in patients receiving radiotherapy for head and neck cancer


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タイトル: A retrospective study of factors associated with the development of oral candidiasis in patients receiving radiotherapy for head and neck cancer
著者: Kawashita, Yumiko / Funahara, Madoka / Yoshimatsu, Masako / Nakao, Noriko / Soutome, Sakiko / Saito, Toshiyuki / Umeda, Masahiro
発行日: 2018年10月10日
出版者: Wolters Kluwer Health, Inc.
引用: Medicine, 97(44), e13073; 2018
抄録: The aims of this study were to investigate the incidence and risk factors for oral candidiasis in patients receiving radiotherapy for head and neck cancer, and to determine the influence of topical steroid therapy on the development of oral candidiasis.We conducted a retrospective study of 300 patients receiving radiotherapy to the head and neck region. The primary endpoint was the incidence of oral candidiasis during radiotherapy. Associations between the incidence of oral candidiasis and various clinical factors were investigated. The cumulative incidence rate of oral candidiasis was calculated using the Kaplan-Meier method and analyzed by the log-rank test and Cox regression. Propensity score-matched analysis was used to assess the influence of topical steroid therapy on the development of oral candidiasis.Oral candidiasis occurred in 75 (25.0%) of the 300 patients. Multivariate analysis identified minimum lymphocyte count and severity of oral mucositis during radiotherapy as independent risk factors for the development of oral candidiasis. Topical steroid therapy for oral mucositis was not associated with the incidence of oral candidiasis according to multivariate and propensity score matching analyses.Oral candidiasis was associated with the suppression of the host's immunity and severe oral mucositis, but not topical steroid therapy. Proper oral health care during radiotherapy and the prevention of severe oral mucositis may reduce the incidence of oral candidiasis.
キーワード: head and neck cancer / oral candidiasis / radiotherapy / retrospective study / supportive care
URI: http://hdl.handle.net/10069/38705
ISSN: 00257974
DOI: 10.1097/MD.0000000000013073
権利: © 2018 the Author(s). Published by Wolters Kluwer Health, Inc. This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY),which permits unrestricted use, distribution,and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0
資料タイプ: Journal Article
原稿種類: publisher
出現コレクション:130 学術雑誌論文

引用URI : http://hdl.handle.net/10069/38705

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