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Screening Validity of Arterial Pressure–Volume Index and Arterial Velocity–Pulse Index for Preclinical Atherosclerosis in Japanese Community-Dwelling Adults: the Nagasaki Islands Study


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タイトル: Screening Validity of Arterial Pressure–Volume Index and Arterial Velocity–Pulse Index for Preclinical Atherosclerosis in Japanese Community-Dwelling Adults: the Nagasaki Islands Study
著者: Yamanashi, Hirotomo / Koyamatsu, Jun / Nagayoshi, Mako / Shimizu, Yuji / Kawashiri, Shin-ya / Kondo, Hideaki / Fukui, Shoichi / Tamai, Mami / Maeda, Takahiro
発行日: 2018年 9月 1日
出版者: 日本動脈硬化学会 / Japan Atherosclerosis Society
引用: Journal of Atherosclerosis and Thrombosis, 25(9), pp.792-798; 2018
抄録: Aim: The arterial pressure–volume index (API) and arterial velocity–pulse index (AVI) are novel measurement indices of arterial stiffness. This study was performed to examine the screening validity of the API and AVI for preclinical atherosclerosis in Japanese community-dwelling adults. Methods: We conducted a cross-sectional study of 2,809 participants aged ≥40 years who underwent Japanese national medical check-ups from 2014 to 2016. Preclinical atherosclerosis was defined as a mean carotid intima–media thickness (CIMT) of ≥ 1.0 mm. Multivariable linear regression analysis was performed to investigate the association of CIMT with API and AVI, adjusting for body mass index, sex, and the Framingham –D'Agostino score. We also examined receiver operating characteristic curves, sensitivity, and specificity to predict preclinical atherosclerosis defined by the CIMT. The cardio-ankle vascular index was also measured for comparison with the API and AVI. Results: Of 2,809 participants, 68 (2.4%) had preclinical atherosclerosis. In the multivariable linear regression analysis, the API and AVI maintained a positive association with the mean CIMT (B =2.6, P =0.009 and B =3.7, P =0.001, respectively). The cut-offs of the API and AVI that demonstrated better sensitivity and specificity for detection of subclinical atherosclerosis were 31 [area under the curve (AUC), 0.64] and 29 (AUC, 0.60). Conclusions: The API and AVI were positively associated with preclinical carotid atherosclerosis independent of the participants' cardiovascular risk. The ability of these scores to predict carotid atherosclerosis could make them a useful screening tool for atherosclerosis.
キーワード: Arterial pressure-volume index / Arterial stiffness / Arterial velocity-pulse index / Carotid intima-media thickness
URI: http://hdl.handle.net/10069/38736
ISSN: 13403478
DOI: 10.5551/jat.43125
権利: © 2018 Japan Atherosclerosis Society. This article is distributed under the terms of the latest version of CC BY-NC-SA defined by the Creative Commons Attribution License.
資料タイプ: Journal Article
原稿種類: publisher
出現コレクション:130 学術雑誌論文

引用URI : http://hdl.handle.net/10069/38736

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