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Anti-MDA5 Antibody-positive Dermatomyositis Complicated by Autoimmune-associated Hemophagocytic Syndrome That Was Successfully Treated with Immunosuppressive Therapy and Plasmapheresis


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タイトル: Anti-MDA5 Antibody-positive Dermatomyositis Complicated by Autoimmune-associated Hemophagocytic Syndrome That Was Successfully Treated with Immunosuppressive Therapy and Plasmapheresis
著者: Fujita, Yuya / Fukui, Shoichi / Suzuki, Takahisa / Ishida, Midori / Endo, Yushiro / Tsuji, Sousuke / Takatani, Ayuko / Igawa, Takashi / Shimizu, Toshimasa / Umeda, Masataka / Sumiyoshi, Remi / Nishino, Ayako / Koga, Tomohiro / Kawashiri, Shin-ya / Iwamoto, Naoki / Ichinose, Kunihiro / Tamai, Mami / Nakamura, Hideki / Origuchi, Tomoki / Abe, Kuniko / Kawakami, Atsushi
発行日: 2018年 7月 6日
出版者: 日本内科学会 / Japanese Society of Internal Medicine
引用: Internal Medicine, 57(23), pp.3473-3478; 2018
抄録: A 56-year-old Japanese woman with muscle weakness, increased creatine kinase and aldolase levels, and characteristic cutaneous lesions was diagnosed with anti-melanoma differentiation-associated gene 5 antibody (anti-MDA5 antibody)-positive dermatomyositis. She also had interstitial lung disease (ILD). After corticosteroid and tacrolimus combination therapy was started, bicytopenia and elevated serum ferritin and trans-aminase emerged. Because the bone marrow tissues were hypoplastic with hemophagocytes, she was diagnosed with concomitant autoimmune-associated hemophagocytic syndrome (HPS). Intravenous cyclophosphamide pulse therapy and plasmapheresis were performed. The laboratory findings indicated improved abnormalities, and the ILD did not progress. Anti-MDA5 antibody-positive dermatomyositis can be complicated by HPS.
キーワード: Anti-MDA5 antibody-positive dermatomyositis / Autoimmune disease / Corticosteroid therapy / Cyclophosphamide / Hemophagocytic syndrome / Plasmapheresis
URI: http://hdl.handle.net/10069/38763
ISSN: 09182918
DOI: 10.2169/internalmedicine.1121-18
権利: ©2018 The Japanese Society of Internal Medicine. The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
資料タイプ: Journal Article
原稿種類: publisher
出現コレクション:130 学術雑誌論文

引用URI : http://hdl.handle.net/10069/38763

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