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Case Report: Concurrent Sympatric Scrub Typhus and Japanese Spotted Fever in Japan


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タイトル: Case Report: Concurrent Sympatric Scrub Typhus and Japanese Spotted Fever in Japan
著者: Sando, Eiichiro / Ogawa, Tomoko / Tanaka, Atsushi / Yaegashi, Makito / Taira, Masakatsu / Ariyoshi, Koya / Fujita, Hiromi / Oshikawa, Yuka / Katoh, Shungo / Paris, Daniel H.
発行日: 2018年12月
出版者: American Society of Tropical Medicine and Hygiene
引用: American Journal of Tropical Medicine and Hygiene, 99(6), pp.1386-1389; 2018
抄録: Scrub typhus and Japanese spotted fever—both rickettsial diseases—are endemic and notifiable in Japan and may cause a fatal outcome without prompt treatment. Here we present the first case of a concurrent sympatric infection of both diseases with grade II evidence. A 67-year-old woman, after a single event of potential exposure to the pathogens, presented with a 12-day history of fever, pharyngeal pain, papulo-erythematous rash, and pronounced fatigue. Her erythematous rash was distributed on her trunk and extremities, palms, and soles and eventually progressed to purpura. Fever persisted until doxycycline was administered on day 12. A significant > 4-fold increase in immunoglobulin G and immunoglobulin M titers against multiple serotypes of Orientia tsutsugamushi and Rickettsia japonica were revealed by indirect immunoperoxidase assays. These clinical and serological data, even in the absence of molecular or isolation evidence, provided grade II evidence that this was a concurrent infection of sympatric scrub typhus and Japanese spotted fever.
URI: http://hdl.handle.net/10069/38765
ISSN: 00029637
DOI: 10.4269/ajtmh.18-0258
権利: © 2018 by The American Society of Tropical Medicine and Hygiene.
資料タイプ: Journal Article
原稿種類: publisher
出現コレクション:120 学術雑誌論文

引用URI : http://hdl.handle.net/10069/38765

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