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Suppressive effect of ascophyllan HS on postprandial blood sugar level through the inhibition of α-glucosidase and stimulation of glucagon-like peptide-1 (GLP-1) secretion


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Title: Suppressive effect of ascophyllan HS on postprandial blood sugar level through the inhibition of α-glucosidase and stimulation of glucagon-like peptide-1 (GLP-1) secretion
Authors: Okimura, Takasi / Jiang, Zedong / Liang, Yan / Yamaguchi, Kenichi / Oda, Tatsuya
Issue Date: 15-Mar-2019
Publisher: Elsevier B.V.
Citation: International Journal of Biological Macromolecules, 125, pp.453-458; 2019
Abstract: A sulfated polysaccharide ascophyllan inhibited α-glucosidase in a concentration dependent manner, and more than 90% activity was inhibited at 1.0 mg/mL. The inhibitory activity was much higher than that of acarbose.No significant inhibitory effect of ascophyllan on α-amylase was observed up to 10.0 mg/mL. Ascophyllan HS, a commercially available ascophyllan preparation showed even higher inhibitory effect on α-glucosidase than ascophyllan. Interestingly, ascophyllan and ascophyllan HS induced the secretion of glucagon-like peptide-1 (GLP-1) from human intestinal NCI-H716 cell line in a concentration dependent manner (10~100 ng/mL). The oral glucose tolerance tests revealed that after continuous 8-week ingestion of ascophyllan HS at 100 mg/day, the glucose area under the curve values of the ascophyllan HS ingested group were significantly lower than placebo ingested group. Serum glycosylated hemoglobin (HbA1c) level in ascophyllan HS ingested group tended to decrease after 8-week ingestion, whereas no significant change was observed in placebo ingested group. This is the first report indicating that ascophyllan can induce the secretion of GLP-1 from human intestinal cell line (NCI-H716), besides the potent inhibitory effect on α-glucosidase.Furthermore, clinical trial suggested that ascophyllan HS may be a practically applicable blood glucose controlling agent in humans.
Keywords: Ascophyllum nodosum / Ascophyllan / Ascophyllan HS / α-glucosidase inhibitor / Secretagogue of GLP-1 / anti-diabetic effect / HbA1c
URI: http://hdl.handle.net/10069/38768
ISSN: 01418130
DOI: 10.1016/j.ijbiomac.2018.12.084
Rights: ©2019, Elsevier. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
Type: Journal Article
Text Version: author
Appears in Collections:Articles in academic journal

Citable URI : http://hdl.handle.net/10069/38768

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