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Association of serum levels of fibrosis-related biomarkers with disease activity in patients with IgG4-related disease


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タイトル: Association of serum levels of fibrosis-related biomarkers with disease activity in patients with IgG4-related disease
著者: Kawashiri, Shin-ya / Origuchi, Tomoki / Umeda, Masataka / Nishino, Ayako / Shimizu, Toshimasa / Fukui, Shoichi / Koga, Tomohiro / Iwamoto, Naoki / Ichinose, Kunihiro / Tamai, Mami / Nakamura, Hideki / Maeda, Takahiro / Kawano, Mitsuhiro / Yamamoto, Motohisa / Izumi, Yasumori / Kawakami, Atsushi
発行日: 2018年12月14日
出版者: BioMed Central Ltd.
引用: Arthritis Research and Therapy, 20(1), art.no.277; 2018
抄録: Background: The aim of this study was to identify fibrosis-related serological surrogate outcome measures in patients with immunoglobulin G4-related disease (IgG4-RD). Methods: This was a clinical observational study of 72 patients with untreated IgG4-RD from four institutions in Japan.The serum concentrations of growth differentiation factor 15 (GDF-15), CCL2, hyaluronic acid (HA), amino-terminal propeptide of type III procollagen (PIIINP), and tissue inhibitor of metalloproteinases 1 (TIMP-1) were measured by enzyme-linked immunosorbent assays. The enhanced liver fibrosis (ELF) score was calculated from the TIMP-1, PIIINP, and HA values. We evaluated associations between the values of these biomarkers and laboratory data, the IgG4-RD responder index (IgG4-RD RI) score, and organ involvements. Results: Compared with the 44 healthy controls, the patients with IgG4-RD showed significantly elevated serum concentrations of GDF-15, MCP-1, HA, PIIINP, and TIMP-1 and ELF scores. The patients' serum concentrations of GDF-15, CCL2, HA, and TIMP-1 (but not PIIINP) were positively correlated with each other. Among them, serum GDF-15 most efficiently distinguished patients with IgG4-RD from healthy controls. Serum GDF-15 was not associated with the IgG4-RD RI score or the number of organ involvements but was independently associated with the presence of retroperitoneal fibrosis and with parotid gland involvement. Conclusions: We observed increased serological surrogate outcome measures of fibrosis in IgG4-RD. GDF-15 may precisely reflect the fibrotic degree in patients with IgG4-RD.
キーワード: IgG4-related disease / Fibrosis / GDF-15 organ involvement / Prednisolone / Responder index
URI: http://hdl.handle.net/10069/38770
DOI: 10.1186/s13075-018-1777-7
権利: ©The Author(s). 2018 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
資料タイプ: Journal Article
原稿種類: publisher
出現コレクション:110 学術雑誌論文

引用URI : http://hdl.handle.net/10069/38770

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