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Membranous Nephropathy with Crescent after Hematopoietic Cell Transplantation

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Title: Membranous Nephropathy with Crescent after Hematopoietic Cell Transplantation
Authors: Kitamura, Mineaki / Hisano, Satoshi / Kurobe, Yuka / Abe, Shinichi / Ota, Yuki / Sawayama, Yasushi / Uramatsu, Tadashi / Obata, Yoko / Fukuoka, Junya / Miyazaki, Yasushi / Mukae, Hiroshi / Nishino, Tomoya
Issue Date: 1-Jan-2019
Publisher: 日本内科学会 / Japanese Society of Internal Medicine
Citation: Internal Medicine, 58(1), pp.91-96; 2019
Abstract: A 44-year-old man who received allogenic hematopoietic stem cell transplantation after being diagnosed with acute myeloid leukemia developed nephrosis when the dose of tacrolimus was tapered. A renal biopsy showed the granular deposition of immunoglobulin G in the glomerular basement membrane and subepithelial electron-dense deposits, crescent formation, C4d-positive staining of the peritubular capillary, and subendothelial swelling, suggesting that the main pathological diagnosis was membranous nephropathy and that chronic graft-versus-host disease played a role in the etiology of nephrosis. We herein report a case of membranous nephropathy with various pathological findings. C4d deposition suggests complement activation and the involvement of humoral factors.
Keywords: graft-versus-host disease / membranous nephropathy / crescent / C4d positivity on peritubular capillaries
URI: http://hdl.handle.net/10069/38787
ISSN: 09182918
DOI: 10.2169/internalmedicine.1251-18
Rights: © 2019 The Japanese Society of Internal Medicine.
Type: Journal Article
Text Version: publisher
Appears in Collections:Articles in academic journal

Citable URI : http://hdl.handle.net/10069/38787

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