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Characteristics of late-onset spondyloarthritis in Japan: A retrospective cohort study


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Title: Characteristics of late-onset spondyloarthritis in Japan: A retrospective cohort study
Authors: Endo, Yushiro / Fujikawa, Keita / Koga, Tomohiro / Mizokami, Akinari / Mine, Masanobu / Tsukada, Toshiaki / Uetani, Masataka / Kawakami, Atsushi
Issue Date: 1-Feb-2019
Publisher: Wolters Kluwer Health, Inc.
Citation: Medicine, 98(7), e14431; 2019
Abstract: Spondyloarthritis may be increasingly present in older patients as life expectancy increases. We investigated clinical differences between early-onset and late-onset spondyloarthritis in Japan. We retrospectively reviewed 114 patients consecutively diagnosed with spondyloarthritis. The clinical course of each patient was observed for ≥1 year. We defined early-onset and late-onset spondyloarthritis as <57 or ≥57 years at a median age of this study group,respectively. We compared clinical characteristics between these 2 groups.Disease duration was significantly shorter before diagnosis in the late-onset group (P < .01). Inflammatory back pain (IBP) was significantly more common in the early-onset group (P < .01), whereas dactylitis frequency was significantly higher in the late-onset group. Significantly more patients with early-onset spondyloarthritis were human leukocyte antigen (HLA) B27-positive (P < .01). Articular synovitis, particularly of the wrist, was significantly more common on power Doppler ultrasound (PDUS) in the late-onset group (P < .01). Tenosynovitis or peritendinitis, particularly in the finger and wrist flexors were also more frequent in the late-onset group (P < .001 and P < .05, respectively). Enthesitis of the finger collateral ligament and lateral collateral ligament were significantly more common in the late-onset group (both P < .05). Multiple logistic regression analysis revealed that, comparatively, IBP was significantly and independently much more likely to occur in the early-onset group.The patients with late-onset spondyloarthritis had a lower frequency of IBP and HLA B27 and a higher frequency of dactylitis and PDUS findings in peripheral involvement.
Keywords: early-onset spondyloarthritis / late-onset spondyloarthritis / peripheral spondyloarthritis / spondyloarthritis
URI: http://hdl.handle.net/10069/38884
ISSN: 00257974
DOI: 10.1097/MD.0000000000014431
Rights: © 2019 the Author(s). Published by Wolters Kluwer Health, Inc. This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Type: Journal Article
Text Version: publisher
Appears in Collections:Articles in academic journal

Citable URI : http://hdl.handle.net/10069/38884

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