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Clinical Features of Anti-MDA5 Antibody-positive Rapidly Progressive Interstitial Lung Disease without Signs of Dermatomyositis


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Title: Clinical Features of Anti-MDA5 Antibody-positive Rapidly Progressive Interstitial Lung Disease without Signs of Dermatomyositis
Authors: Sakamoto, Noriho / Ishimoto, Hiroshi / Nakashima, Shota / Yura, Hirokazu / Miyamura, Takuto / Okuno, Daisuke / Hara, Atsuko / Kitazaki, Takeshi / Kakugawa, Tomoyuki / Ishimatsu, Yuji / Satoh, Minoru / Mukae, Hiroshi
Issue Date: 15-Mar-2019
Publisher: 日本内科学会 / The Japanese Society of Internal Medicine
Citation: Internal medicine, 58(6), pp.837-841; 2019 
Abstract: Anti-melanoma differentiation-associated gene 5 (anti-MDA5) antibody is associated with rapidly progressive interstitial lung disease (RP-ILD) in patients with clinically amyopathic dermatomyositis (CADM) or dermatomyositis (DM). We herein report three Japanese cases of anti-MDA5 antibody-positive RP-ILD without signs of CADM or DM. High-resolution computed tomography revealed patchy or subpleural distribution of consolidations and/or ground-glass opacities accompanied by traction bronchiectasis. All patients succumbed to respiratory failure within two months. Anti-MDA5 antibody-positive RP-ILD without signs of CADM or DM should be included in the differential diagnosis of acute/subacute ILD. Measurement of anti-MDA5 antibody and an intensive immunosuppressive regimen might rescue these patients from RP-ILD.
Keywords: acute interstitial pneumonia / anti-melanoma differentiation-associated gene 5 / clinically amyopathic dermatomyositis
URI: http://hdl.handle.net/10069/38963
ISSN: 09182918
DOI: 10.2169/internalmedicine.1516-18
Rights: © 2019 The Japanese Society of Internal Medicine. The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
Type: Journal Article
Text Version: publisher
Appears in Collections:Articles in academic journal

Citable URI : http://hdl.handle.net/10069/38963

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